A randomized, controlled trial of vitamin D supplementation upon musculoskeletal health in postmenarchal females
Ward KA, Das G, Roberts SA, Berry JL, Adams JE, Rawer R, Mughal MZ
The Journal of clinical endocrinology and metabolism · 106 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Medical Research Council
Según 1 financiador declarado.
Publicación
- Publicado
- 2010-07-15 · J Clin Endocrinol Metab · vol. 95 · número 10 · págs. 4643–4651
- Editorial
- Oxford University Press
- Citado
- 163 citas · más que el 99% de estudios similares · 9.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Vitamin K Research Studies
- Palabras clave
- vitamin D supplementation, vitamin D2, vitamin D deficiency, adolescent girls, musculoskeletal health, bone mineral accrual, muscle function, jump velocity, 25-hydroxyvitamin D, bone geometry, bone strength, rickets
- MeSH
- humans, vitamin d deficiency, vitamin d, absorptiometry, photon, hand strength, feasibility studies, double-blind method, health status, menarche, bone density, dietary supplements, adolescent, child, female, musculoskeletal physiological phenomena
7 autores
- Kate Anna Ward🇬🇧 · autor de correspondenciaUniversity of Manchester; Medical Research Council
- G. Das🇬🇧National Health Service
- Stephen A. Roberts🇬🇧Manchester Academic Health Science Centre; University of Manchester
- Jacqueline Berry🇬🇧University of Manchester
- Judith E. Adams🇬🇧Manchester Royal Infirmary; University of Manchester
- Rainer Rawer
- Zulf Mughal🇬🇧Royal Manchester Children's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
There has been a resurgence of vitamin D deficiency rickets throughout the developed world, with infants and adolescents being primarily affected. Adolescence is a crucial period for muscle and bone mineral accumulation.
Objective
The aim was to determine the effect of vitamin D supplementation on the adolescent musculoskeletal system.
Design and setting
We conducted a community-based, double-blind, randomized controlled trial in a secondary school.
Participants
Postmenarchal 12- to 14-yr-old females participated in the trial. Ninety-nine were screened, 73 were included in randomized controlled trial, and 69 completed the trial. There were no adverse events.
Intervention
Four doses of 150,000 IU vitamin D(2) (ergocalciferol) were given over 1 yr.
Main outcome measures
Dual-energy x-ray absorptiometry, peripheral quantitative computed tomography, and jumping mechanography were used.
Results
At follow-up, 25-hydroxyvitamin D [25(OH)D] status was 56.0 ± 8.9 nmol/liter in the intervention group and 15.8 ± 6.6 nmol/liter in controls. There were no effects of supplementation on bone; however, for muscle function, efficiency of movement improved in the vitamin D-treated group. There was an interaction between baseline 25(OH)D concentration and response to vitamin D supplementation for muscle jump velocity.
Conclusions
Despite improvements in 25(OH)D status, treatment with vitamin D(2) was not shown to increase mineral accretion, bone geometry or strength, muscle force, or power. There were greater increases in jump velocity in girls with the lowest baseline 25(OH)D concentrations. Lack of effect of intervention after the period of peak mineral and muscle mass accretion suggests that earlier action is required.
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