A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness
Dong Y, Stallmann-Jorgensen IS, Pollock NK, Harris RA, Keeton D, Huang Y, Li K, Bassali R, Guo DH, Thomas J, Pierce GL, White J, Holick MF, Zhu H
The Journal of clinical endocrinology and metabolism · 185 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-07-22 · J Clin Endocrinol Metab · vol. 95 · número 10 · págs. 4584–4591
- Editorial
- Oxford University Press
- Citado
- 247 citas · más que el 99% de estudios similares · 16.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Cardiovascular Health and Disease Prevention
- Palabras clave
- vitamin D3 supplementation, vitamin D insufficiency, 25-hydroxyvitamin D, Black youth, adolescents, fat mass, adiposity, arterial stiffness, pulse wave velocity, carotid-femoral pulse wave velocity, vitamin D deficiency prevention, cardiovascular risk factors, dietary fat intake
- MeSH
- arteries, humans, cardiovascular diseases, cholecalciferol, calcifediol, ultrasonography, drug administration schedule, single-blind method, dose-response relationship, drug, time factors, dietary supplements, adolescent, female, male, adiposity, black people
14 autores
- Yanbin Dong🇺🇸Augusta University
- Inger Susanne Stallmann-Jorgensen🇺🇸Augusta University
- Norman K. Pollock🇺🇸Augusta University
- Ryan Alan Harris🇺🇸Augusta University
- Daniel Keeton🇺🇸Augusta University
- Ying Huang🇺🇸Augusta University
- Ke Li🇺🇸Augusta University
- Reda W. Bassali🇺🇸Augusta University
- De-Huang Guo🇺🇸Augusta University
- Jeffrey Thomas🇺🇸Augusta University
- Gary L. Pierce🇺🇸Augusta University
- Jennifer R. White🇺🇸Augusta University
- Michael F. Holick🇺🇸Boston University; Boston Medical Center
- Haidong Zhu🇺🇸 · autor de correspondenciaAugusta University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Vitamin D insufficiency/deficiency is commonly observed in black youth.
Objective
The aim was to determine 25-hydroxyvitamin D [25(OH)D] in response to 2000 IU vitamin D supplementation over time; to evaluate the relation between 25(OH)D concentrations and total body fat mass by dual-energy x-ray absorptiometry; and to determine whether vitamin D supplementation improves arterial stiffness measured by pulse wave velocity (PWV).
Design
We conducted a randomized, blinded, controlled clinical trial.
Setting and participants
Forty-nine normotensive black boys and girls, aged 16.3 ± 1.4 yr, were randomly assigned to either the control group (400 IU/d; n = 24) or the experimental group (2000 IU/d; n = 25).
Results
Plasma 25(OH)D values at baseline and at 4, 8, and 16 wk were 34.0 ± 10.6, 44.9 ± 9.4, 51.2 ± 11.1, and 59.8 ± 18.2 nmol/liter, respectively, for the control group; and 33.1 ± 8.7, 55.0 ± 11.8, 70.9 ± 22.0, and 85.7 ± 30.1 nmol/liter, respectively, for the experimental group. The experimental group vs. the control group reached significantly higher 25(OH)D concentrations at 8 and 16 wk, respectively. Partial correlation analyses indicated that total body fat mass at baseline was significantly and inversely associated with 25(OH)D concentrations in response to the 2000-IU supplement across time. Furthermore, carotid-femoral PWV increased from baseline (5.38 ± 0.53 m/sec) to posttest (5.71 ± 0.75 m/sec) in the control group (P = 0.016), whereas in the experimental group carotid-femoral PWV decreased from baseline (5.41 ± 0.73 m/sec) to posttest (5.33 ± 0.79 m/sec) (P = 0.031).
Conclusion
Daily 2000 IU vitamin D supplementation may be effective in optimizing vitamin D status and counteracting the progression of aortic stiffness in black youth. Plasma 25(OH)D concentrations in response to the 2000 IU/d supplementation are negatively modulated by adiposity.
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