Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome
Basu A, Du M, Leyva MJ, Sanchez K, Betts NM, Wu M, Aston CE, Lyons TJ
The Journal of nutrition · 299 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Oklahoma
- Gobierno
- National Institutes of Health
- Universidad u hospital
- University of Oklahoma Health Sciences Center
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Subvenciones
- University of Oklahoma (M01-RR14467); National Center for Research Resources (M01 RR-14467); National Center for Research Resources (M01RR014467); National Center for Research Resources (RR 14467); University of Oklahoma Health Sciences Center (M01-RR14467)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2010-07-22 · J Nutr · vol. 140 · número 9 · págs. 1582–1587
- Editorial
- Elsevier BV
- Citado
- 507 citas · más que el 99% de estudios similares · 12.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Nutritional Studies and Diet · Pomegranate: compositions and health benefits
- Palabras clave
- metabolic syndrome, obesity, cardiovascular risk factors, blood pressure, oxidized LDL, lipid peroxidation, malondialdehyde, 4-hydroxynonenal, polyphenols, serum glucose, lipid profile
- MeSH
- humans, cardiovascular diseases, obesity, freeze drying, blood pressure, beverages, middle aged, female, male, metabolic syndrome
8 autores
- Arpita Basu🇺🇸 · autor de correspondenciaOklahoma State University
- Mei Du🇺🇸University of Oklahoma Health Sciences Center
- Misti J. Leyva🇺🇸University of Oklahoma Health Sciences Center
- Karah Sanchez🇺🇸Oklahoma State University
- Nancy M. Betts🇺🇸Oklahoma State University
- Mingyuan Wu🇺🇸University of Oklahoma Health Sciences Center
- Christopher E. Aston🇺🇸University of Oklahoma Health Sciences Center
- Timothy J. Lyons🇺🇸University of Oklahoma Health Sciences Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Among all fruits, berries have shown substantial cardio-protective benefits due to their high polyphenol content. However, investigation of their efficacy in improving features of metabolic syndrome and related cardiovascular risk factors in obesity is limited. We examined the effects of blueberry supplementation on features of metabolic syndrome, lipid peroxidation, and inflammation in obese men and women. Forty-eight participants with metabolic syndrome [4 males and 44 females; BMI: 37.8 +/- 2.3 kg/m(2); age: 50.0 +/- 3.0 y (mean +/- SE)] consumed freeze-dried blueberry beverage (50 g freeze-dried blueberries, approximately 350 g fresh blueberries) or equivalent amounts of fluids (controls, 960 mL water) daily for 8 wk in a randomized controlled trial. Anthropometric and blood pressure measurements, assessment of dietary intakes, and fasting blood draws were conducted at screening and at wk 4 and 8 of the study. The decreases in systolic and diastolic blood pressures were greater in the blueberry-supplemented group (- 6 and - 4%, respectively) than in controls (- 1.5 and - 1.2%) (P lt 0.05), whereas the serum glucose concentration and lipid profiles were not affected. The decreases in plasma oxidized LDL and serum malondialdehyde and hydroxynonenal concentrations were greater in the blueberry group (- 28 and - 17%, respectively) than in the control group (- 9 and - 9%) (P lt 0.01). Our study shows blueberries may improve selected features of metabolic syndrome and related cardiovascular risk factors at dietary achievable doses.
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