Effect of increased consumption of whole-grain foods on blood pressure and other cardiovascular risk markers in healthy middle-aged persons: a randomized controlled trial
Tighe P, Duthie G, Vaughan N, Brittenden J, Simpson WG, Duthie S, Mutch W, Wahle K, Horgan G, Thies F
The American journal of clinical nutrition · 195 citas
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Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-08-05 · Am J Clin Nutr · vol. 92 · número 4 · págs. 733–740
- Editorial
- Elsevier BV
- Citado
- 305 citas · más que el 100% de estudios similares · 18.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Blood Pressure and Hypertension Studies
- Palabras clave
- whole grains, blood pressure, cardiovascular risk factors, wheat, oat, dietary intervention, middle-aged adults, pulse pressure, cholesterol, insulin sensitivity, inflammation, lipid profile, coronary artery disease, stroke
- MeSH
- humans, triticum, cardiovascular diseases, inflammation, dietary carbohydrates, polysaccharides, lipids, dietary fats, single-blind method, blood pressure, reference values, adult, aged, middle aged, female, male, avena, edible grain
10 autores
- Paula Tighe🇬🇧University of Aberdeen
- Garry G. Duthie
- Nicholas J. Vaughan
- Julie Brittenden
- William G. Simpson
- Susan J. Duthie
- William James Mutch
- Klaus W.J. Wahle
- Graham William Horgan
- Frank Thiès
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Three daily portions of whole-grain foods could lower cardiovascular disease risk, but a comprehensive intervention trial was needed to confirm this recommendation.
Objectives
We aimed to assess the effects of consumption of 3 daily portions of whole-grain foods (provided as only wheat or a mixture of wheat and oats) on markers of cardiovascular disease risk in relatively high-risk individuals.
Design
This was a randomized controlled dietary trial in middle-aged healthy individuals. After a 4-wk run-in period with a refined diet, we randomly allocated volunteers to a control (refined diet), wheat, or wheat + oats group for 12 wk. The primary outcome was a reduction of cardiovascular disease risk factors by dietary intervention with whole grains, which included lipid and inflammatory marker concentrations, insulin sensitivity, and blood pressure.
Results
We recruited a total of 233 volunteers; 24 volunteers withdrew, and 3 volunteers were excluded. Systolic blood pressure and pulse pressure were significantly reduced by 6 and 3 mm Hg, respectively, in the whole-grain foods groups compared with the control group. Systemic markers of cardiovascular disease risk remained unchanged apart from cholesterol concentrations, which decreased slightly but significantly in the refined group.
Conclusions
Daily consumption of 3 portions of whole-grain foods can significantly reduce cardiovascular disease risk in middle-aged people mainly through blood pressure-lowering mechanisms. The observed decrease in systolic blood pressure could decrease the incidence of coronary artery disease and stroke by ≥15% and 25%, respectively. This trial was registered at clinicaltrials.gov as ISRCTN27657880.
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