Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies
Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN, Hivert MF, Ngwa J, van Rooij FJ, Sonestedt E, Wojczynski MK, Ye Z, Tanaka T, Garcia M, Anderson JS, Follis JL, Djousse L, Mukamal K, Papoutsakis C, Mozaffarian D, Zillikens MC, Bandinelli S, Bennett AJ, Borecki IB, Feitosa MF, Ferrucci L, Forouhi NG, Groves CJ, Hallmans G, Harris T, Hofman A, Houston DK, Hu FB, Johansson I, Kritchevsky SB, Langenberg C, Launer L, Liu Y, Loos RJ, Nalls M, Orho-Melander M, Renstrom F, Rice K, Riserus U, Rolandsson O, Rotter JI, Saylor G, Sijbrands EJ, Sjogren P, Smith A, Steingrímsdóttir L, Uitterlinden AG, Wareham NJ, Prokopenko I, Pankow JS, van Duijn CM, Florez JC, Witteman JC, MAGIC Investigators, Dupuis J, Dedoussis GV, Ordovas JM, Ingelsson E, Cupples L, Siscovick DS, Franks PW, Meigs JB
Diabetes care · 99 citas
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- Financiación independiente
- Gobierno
- U.S. Department of Agriculture
- Universidad u hospital
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- Wellcome Trust
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- British Heart Foundation
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- Hjartavernd
- Gobierno
- National Institute on Aging
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- National Heart, Lung, and Blood Institute
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- Medical Research Council
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- NHLBI NIH HHS
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- NIA NIH HHS
- Subvenciones
- National Institute on Aging (R01AG032098); National Heart, Lung, and Blood Institute (R01-HL087700); British Heart Foundation (RG/07/008/23674)
Según 22 financiadores declarados.
Publicación
- Publicado
- 2010-08-06 · Diabetes Care · vol. 33 · número 12 · págs. 2684–2691
- Editorial
- American Diabetes Association
- Citado
- 139 citas · más que el 98% de estudios similares · 7.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Nutrition, Genetics, and Disease · Food composition and properties · Genetic Associations and Epidemiology
- Palabras clave
- whole grain intake, dietary intake, fasting blood glucose, fasting insulin, genetic loci, gene-diet interaction, single nucleotide polymorphisms, GCKR, rs780094, insulin sensitivity, type 2 diabetes risk, European ancestry
- MeSH
- humans, insulin, blood glucose, fasting, genotype, polymorphism, single nucleotide, adult, aged, middle aged, female, male, genome-wide association study, genetic loci, edible grain, white people
12 autores
- Jennifer A. Nettleton🇺🇸 · autor de correspondenciaThe University of Texas Health Science Center at Houston
- Nicola Mary McKeown🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Stavroula Kanoni🇬🇷Harokopio University of Athens
- Rozenn N. Lemaître🇺🇸University of Washington
- Marie‐France Hivert🇨🇦Université de Sherbrooke
- Julius Suh Ngwa🇺🇸Boston University
- Frank J.A. van Rooij🇳🇱Erasmus MC; Netherlands Consortium for Healthy Ageing
- Emily Sonestedt🇸🇪Lund University
- Mary K. Wojczynski🇺🇸Washington University in St. Louis
- Zheng Ye🇬🇧Addenbrooke's Hospital; MRC Epidemiology Unit; Medical Research Council
- Tosh Tanaka🇺🇸National Institute on Aging
- the CHARGE Whole Grain Foods Study Group
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Whole-grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in individuals free of diabetes. We tested the hypothesis that whole-grain food intake and genetic variation interact to influence concentrations of fasting glucose and insulin.
Research design and methods
Via meta-analysis of data from 14 cohorts comprising ∼ 48,000 participants of European descent, we studied interactions of whole-grain intake with loci previously associated in GWAS with fasting glucose (16 loci) and/or insulin (2 loci) concentrations. For tests of interaction, we considered a P value <0.0028 (0.05 of 18 tests) as statistically significant.
Results
Greater whole-grain food intake was associated with lower fasting glucose and insulin concentrations independent of demographics, other dietary and lifestyle factors, and BMI (β [95% CI] per 1-serving-greater whole-grain intake: -0.009 mmol/l glucose [-0.013 to -0.005], P < 0.0001 and -0.011 pmol/l [ln] insulin [-0.015 to -0.007], P = 0.0003). No interactions met our multiple testing-adjusted statistical significance threshold. The strongest SNP interaction with whole-grain intake was rs780094 (GCKR) for fasting insulin (P = 0.006), where greater whole-grain intake was associated with a smaller reduction in fasting insulin concentrations in those with the insulin-raising allele.
Conclusions
Our results support the favorable association of whole-grain intake with fasting glucose and insulin and suggest a potential interaction between variation in GCKR and whole-grain intake in influencing fasting insulin concentrations.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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