Caffeine self-administration, withdrawal, and adverse effects among coffee drinkers
Hughes JR, Higgins ST, Bickel WK, Hunt WK, Fenwick JW, Gulliver SB, Mireault GC
Archives of general psychiatry · 84 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Drug Abuse
- Gobierno
- NIDA NIH HHS
- Subvenciones
- National Institute on Drug Abuse (DA-04545); National Institute on Drug Abuse (DA-04843); National Institute on Drug Abuse (DA00109)
Según 2 financiadores declarados.
Publicación
- Publicado
- 1991-07-01 · Arch Gen Psychiatry · vol. 48 · número 7 · pág. 611
- Editorial
- American Medical Association
- Citado
- 140 citas · más que el 99% de estudios similares · 9.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 29 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Substance Abuse Treatment and Outcomes · Neurotransmitter Receptor Influence on Behavior
- Palabras clave
- caffeine withdrawal, caffeine dependence, decaffeinated coffee, headache, fatigue, sleepiness
- MeSH
- humans, tremor, headache, substance-related disorders, substance withdrawal syndrome, caffeine, self medication, double-blind method, sleep stages, coffee, adult, middle aged, female, male
1 autor
- John Russell Hughes🇺🇸 · autor de correspondenciaUniversity of Vermont
Resumen
El texto original del estudio, en el idioma en que se publicó.
Twenty-two coffee drinkers (three to seven cups per day) underwent repeated double-blind trials to test for caffeine self-administration, withdrawal, and adverse effects. Each trial consisted first of a randomized crossover period of 1 day of decaffeinated coffee and 1 day of caffeinated coffee (100 mg) to assess withdrawal and adverse effects of caffeine. Next, subjects were given 2 days of concurrent access to the two coffees. The relative use of the two coffees was used to assess caffeine self-administration. Reliable caffeine self-administration occurred in three of 10 subjects in study 1 and seven of 12 subjects in study 2. Withdrawal symptoms were headaches, drowsiness, and fatigue. The major adverse effect from self-administration was tremulousness. The occurrence of headaches on substitution of decaffeinated coffee prospectively predicted subsequent self-administration of caffeine. These results indicate that some coffee drinkers exhibit signs of a caffeine dependence, ie, they self-administer coffee for the effects of caffeine, have withdrawal symptoms on cessation, and experience adverse effects.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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