Clinic-epidemiological evaluation of ulcers in patients with leprosy sequelae and the effect of low level laser therapy on wound healing: a randomized clinical trial
Barreto JG, Salgado CG
BMC infectious diseases · 26 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Gobierno
- Financiadora de Estudos e Projetos
- Gobierno
- Ministério da Saúde
- Universidad u hospital
- Universidade Federal do Pará
- Gobierno
- Ministério da Ciência e Tecnologia
- Gobierno
- Fundação Amparo e Desenvolvimento da Pesquisa
- Universidad u hospital
- Pró-Reitoria de Pesquisa e Pós-Graduação, Universidade Federal do Pará
Según 8 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2010-08-10 · BMC Infect Dis · vol. 10 · número 1 · pág. 237
- Editorial
- BioMed Central
- Citado
- 55 citas · más que el 76% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Leprosy Research and Treatment · Laser Applications in Dentistry and Medicine · Leech Biology and Applications
- Palabras clave
- leprosy sequelae, leprosy ulcers, low-level laser therapy, wound healing, peripheral nerve injury, ulcer depth, pressure ulcer healing, Mycobacterium leprae, Brazilian Amazon
- MeSH
- humans, leprosy, skin ulcer, treatment outcome, wound healing, adolescent, adult, aged, aged, 80 and over, middle aged, brazil, female, male, young adult, low-level light therapy
2 autores
- Josafá Gonçalves Barreto🇧🇷Universidade do Estado do Pará; Universidade Federal do Pará
- Cláudio Guedes Salgado🇧🇷 · autor de correspondenciaUniversidade do Estado do Pará; Universidade Federal do Pará
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Mycobacterium leprae is the only pathogenic bacteria able to infect peripheral nerves. Neural impairment results in a set of sensitive, motor and autonomic disturbances, with ulcers originating primarily on the hands and feet. The study objectives were to analyze the clinic-epidemiological characteristics of patients attended at one specialized dressing service from a leprosy-endemic region of the Brazilian Amazon and to evaluate the effect of low level laser therapy (LLLT) on wound healing of these patients.
Methods
Clinic-epidemiological evaluation of patients with leprosy sequelae was performed at the reference unit in sanitary dermatology of the state of Pará in Brazil. We conducted anamnesis, identification of the regions affected by the lesions and measurement of ulcer depth and surface area. After that, we performed a randomized clinical trial. Fifty-one patients with ulcers related to leprosy were evaluated, twenty-five of them were randomly assigned to a low level laser therapy group or a control group. Patients were treated 3 times per week for 12 weeks. Outcome measures were ulcer surface area, ulcer depth and the pressure ulcer scale for healing score (PUSH).
Results
Ninety-seven ulcers were identified, with a mean (SD) duration of 97.6 (111.7) months, surface area of 7.3 (11.5) cm2, and depth of 6.0 (6.2) mm. Statistical analysis of the data determined that there were no significant differences in the variables analyzed before and after treatment with low level laser therapy.
Conclusions
Ulcers in patients with leprosy remain a major source of economic and social losses, even many years after they have been cured of M. leprae infection. Our results indicate that it is necessary to develop new and more effective therapeutic tools, as low level laser therapy did not demonstrate any additional benefits to ulcer healing with the parameters used in this study.
Trial registration
The trial was registered at ClinicalTrials.gov as NCT00860717.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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