Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise
Vanhatalo A, Bailey SJ, Blackwell JR, DiMenna FJ, Pavey TG, Wilkerson DP, Benjamin N, Winyard PG, Jones AM
American journal of physiology. Regulatory, integrative and comparative physiology · 359 citas
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- Ensayo controlado aleatorizado (indexado por PubMed)
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Quién lo pagó
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- Financiación no declarada
Publicación
- Publicado
- 2010-08-11 · Am J Physiol Regul Integr Comp Physiol · vol. 299 · número 4 · págs. R1121–R1131
- Editorial
- American Physiological Society
- Citado
- 530 citas · más que el 100% de estudios similares · 80.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular and exercise physiology · High Altitude and Hypoxia · Heart Rate Variability and Autonomic Control
- Palabras clave
- Dietary Nitrate, Blood pressure, Nitrate, Intensity (physics), Medicine, Internal medicine, Physical therapy, Physiology, Animal science, Biology, Ecology
- MeSH
- humans, beta vulgaris, nitrates, nitric oxide, lactic acid, exercise test, pulmonary gas exchange, exercise, cross-over studies, oxygen consumption, anaerobic threshold, blood pressure, respiratory mechanics, physical fitness, dietary supplements, adult, female, male
9 autores
- Anni Vanhatalo
- Stephen J. Bailey
- Jamie R. Blackwell
- Fred J. DiMenna
- Toby Pavey🇬🇧University of Exeter; Peninsula College of Medicine and Dentistry
- Daryl Paul Wilkerson
- Nigel Benjamin🇬🇧University of Exeter; Peninsula College of Medicine and Dentistry
- Paul Graham Winyard🇬🇧University of Exeter; Peninsula College of Medicine and Dentistry
- ANDREW MARK JONES · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary nitrate (NO(3)(-)) supplementation with beetroot juice (BR) over 4-6 days has been shown to reduce the O(2) cost of submaximal exercise and to improve exercise tolerance. However, it is not known whether shorter (or longer) periods of supplementation have similar (or greater) effects. We therefore investigated the effects of acute and chronic NO(3)(-) supplementation on resting blood pressure (BP) and the physiological responses to moderate-intensity exercise and ramp incremental cycle exercise in eight healthy subjects. Following baseline tests, the subjects were assigned in a balanced crossover design to receive BR (0.5 l/day; 5.2 mmol of NO(3)(-)/day) and placebo (PL; 0.5 l/day low-calorie juice cordial) treatments. The exercise protocol (two moderate-intensity step tests followed by a ramp test) was repeated 2.5 h following first ingestion (0.5 liter) and after 5 and 15 days of BR and PL. Plasma nitrite concentration (baseline: 454 ± 81 nM) was significantly elevated (+39% at 2.5 h postingestion; +25% at 5 days; +46% at 15 days; P < 0.05) and systolic and diastolic BP (baseline: 127 ± 6 and 72 ± 5 mmHg, respectively) were reduced by ∼4% throughout the BR supplementation period (P < 0.05). Compared with PL, the steady-state Vo(2) during moderate exercise was reduced by ∼4% after 2.5 h and remained similarly reduced after 5 and 15 days of BR (P < 0.05). The ramp test peak power and the work rate at the gas exchange threshold (baseline: 322 ± 67 W and 89 ± 15 W, respectively) were elevated after 15 days of BR (331 ± 68 W and 105 ± 28 W; P < 0.05) but not PL (323 ± 68 W and 84 ± 18 W). These results indicate that dietary NO(3)(-) supplementation acutely reduces BP and the O(2) cost of submaximal exercise and that these effects are maintained for at least 15 days if supplementation is continued.
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