The effect of caffeine on intraocular pressure: a systematic review and meta-analysis
Li M, Wang M, Guo W, Wang J, Sun X
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 47 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-08-12 · Graefes Arch Clin Exp Ophthalmol · vol. 249 · número 3 · págs. 435–442
- Editorial
- Springer Science+Business Media
- Citado
- 65 citas · más que el 49% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 50 trabajos
- Acceso
- De pago
- Áreas de investigación
- Glaucoma and retinal disorders · Coffee research and impacts · Blood Pressure and Hypertension Studies
- Palabras clave
- caffeine, intraocular pressure, glaucoma, ocular hypertension, caffeine ingestion, normal individuals
- MeSH
- humans, ocular hypertension, glaucoma, caffeine, tonometry, ocular, intraocular pressure, adult, female, male, randomized controlled trials as topic, young adult
5 autores
- Mao Li🇨🇳Shanghai Medical College of Fudan University; Fudan University
- Min Wang🇨🇳Shanghai Medical College of Fudan University; Fudan University
- Wenyi Guo🇨🇳Shanghai Medical College of Fudan University; Fudan University
- Jiajian Wang🇨🇳Shanghai Medical College of Fudan University; Fudan University
- Xinghuai Sun🇨🇳 · autor de correspondenciaShanghai Medical College of Fudan University; Fudan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Caffeine is widely consumed, and its effect on intraocular pressure (IOP) has been reported in conflicting data. The aim of this meta-analysis was to quantitatively summarize the effect of caffeine on IOP in normal individuals and in patients with glaucoma or ocular hypertension (OHT).
Methods
A comprehensive literature search was performed using the Cochrane Collaboration methodology to identify pertinent randomized controlled trials (RCTs) from the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed and EMBASE. A systematic review and meta-analysis was performed. IOP at 0.5 hour (h), 1 h and 1.5 h after caffeine ingestion was the main outcome measurement.
Results
Six RCTs (two parallel-designed and four crossover-designed) evaluating 144 participants fulfilled inclusion criteria. The risk of bias for these studies was uncertain. Among the participants, 103 were normal individuals and 41 were patients with glaucoma or OHT. In normal individuals, the IOPs measured at 0.5 h, 1 h and 1.5 h post-intervention were not affected by ingestion of caffeine. The weighted mean difference (WMD) with 95% confidence intervals (95%CI) for each measurement point were -0.740 (-2.454, 0.974), 0.522 (-0.568, 1.613) and 0.580 (-1.524, 2.684). However, in patients with glaucoma or OHT, IOP increased at each measurement point, with the WMD and 95%CI being 0.347 (0.078, 0.616), 2.395 (1.741,3.049) and 1.998 (1.522,2.474) respectively. No publication bias was detected by either Begg's or Egger's test.
Conclusion
Available evidences showed that caffeine had different effects on IOP in different groups of individuals. For normal individuals, IOP was not changed by ingestion of caffeine, while for patients with glaucoma or OHT, IOP increased significantly. More high-quality RCTs are warranted to confirm this. The mechanisms underlying this phenomenon and the clinical significance are to be explored.
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