Effects of docosahexaenoic acid supplementation during pregnancy on gestational age and size at birth: randomized, double-blind, placebo-controlled trial in Mexico
Ramakrishnan U, Stein AD, Parra-Cabrera S, Wang M, Imhoff-Kunsch B, Juárez-Márquez S, Rivera J, Martorell R
Food and nutrition bulletin · 129 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Gobierno
- NICHD NIH HHS
- Subvenciones
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-043099); Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD043099)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2010-06-01 · Food Nutr Bull · vol. 31 · número 2_suppl2 · págs. S108–S116
- Editorial
- SAGE Publishing
- Citado
- 199 citas · más que el 98% de estudios similares · 9.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Birth, Development, and Health · Pregnancy and preeclampsia studies
- Palabras clave
- docosahexaenoic acid, omega-3 fatty acids, prenatal supplementation, gestational age, birth weight, birth size, head circumference, primigravida, multigravidae, birth outcomes, infant brain development, Mexico, Cuernavaca, low-income populations, stillbirth
- MeSH
- head, humans, pregnancy complications, fetal growth retardation, premature birth, birth weight, docosahexaenoic acids, body size, pregnancy outcome, double-blind method, gravidity, aging, gestational age, pregnancy, dietary supplements, adolescent, adult, infant, infant, newborn, urban population, mexico, female, male, prenatal nutritional physiological phenomena, young adult
8 autores
- Usha Ramakrishnan🇺🇸Emory University
- Aryeh D. Stein
- Socorro Parra‐Cabrera
- Meng Wang
- Beth Imhoff‐Kunsch
- Sergio Juárez-Márquez
- Juan Á. Rivera
- Reynaldo Martorell
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The need for omega-3 fatty acids, especially docosahexaenoic acid (DHA), during pregnancy has received much attention, but evidence of effects on birth outcomes is limited.
Objective
To evaluate whether prenatal DHA supplementation increases gestational age and birth size.
Methods
We conducted a double-blind, randomized, placebo-controlled trial in Cuernavaca, Mexico. We randomly assigned 1,094 pregnant women (18 to 35 years of age; median DHA dietary intake, 55 mg/day) to 400 mg/day of algal DHA or placebo from 18 to 22 weeks of gestation through delivery. Birth outcomes (968 live births and 5 stillbirths) were ascertained from hospital records within 24 hours of delivery.
Results
Intention-to-treat analysis showed no differences between the control and DHA group (all p > .05) in mean gestational age (39.1 + 1.7 and 39.0 +/- 1.9 weeks, respectively), weight (3.20 + 0.47 and 3.21 +/- 0.45 kg, respectively), length (50.3 +/- 2.7 and 50.3 +/- 2.3 cm, respectively) and head circumference (34.3 +/- 1.8 and 34.3 +/- 1.5 cm, respectively) at birth. Offspring of supplemented primigravidae (n = 370) were heavier (difference, 99.4 g; 95% CI, 5.5 to 193.4) and had larger head circumferences (difference, 0.5 cm; 95% CI, 0.1 to 0.9) than controls; the differences in multigravidae (n = 603) were -53.3 g (95% CI, -126.8 to 20.2) and -0.2 cm (95% CI, -0.4 to 0.1), respectively (p < .05 for heterogeneity).
Conclusions
Prenatal DHA supplementation of primigravid women may result in increased birth size in a population where dietary DHA intakes are very low. Benefits of the intervention on infant health and neurodevelopment are under study.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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