Effects of vitamin D supplementation to children diagnosed with pneumonia in Kabul: a randomised controlled trial
Manaseki-Holland S, Qader G, Isaq Masher M, Bruce J, Zulf Mughal M, Chandramohan D, Walraven G
Tropical medicine & international health : TM & IH · 132 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-08-17 · Trop Med Int Health · vol. 15 · número 10 · págs. 1148–1155
- Editorial
- Wiley
- Citado
- 186 citas · más que el 99% de estudios similares · 10.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Pneumonia and Respiratory Infections · Respiratory viral infections research
- Palabras clave
- vitamin D supplementation, vitamin D3, pediatric pneumonia, recurrent pneumonia, disease duration, antibiotic therapy, young children
- MeSH
- humans, pneumonia, recurrence, vitamins, vitamin d, anti-bacterial agents, severity of illness index, incidence, follow-up studies, double-blind method, dietary supplements, infant, afghanistan, female, male, kaplan-meier estimate
7 autores
- Semira Manaseki‐Holland🇦🇫 · autor de correspondenciaKabul University of Medical Sciences Abu Ali Ibn Sina
- Ghulam Qader
- Mohammad Isaq Masher🇦🇫Kabul University of Medical Sciences Abu Ali Ibn Sina
- Jane Bruce🇬🇧London School of Hygiene & Tropical Medicine
- Zulf Mughal🇬🇧Royal Manchester Children's Hospital
- Daniel Chandramohan🇬🇧London School of Hygiene & Tropical Medicine
- Gijs E. L. Walraven
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To determine whether (i) supplementation of oral 100,000 iu of vitamin D(3) (cholecalciferol) along with antibiotics will reduce the duration of illness in children with pneumonia; (ii) supplementation will reduce the risk of repeat episodes.
Methods
Double-blind individually randomised placebo-controlled trial in an inner-city hospital in Kabul, of 453 children aged 1-36 months, diagnosed with non-severe or severe pneumonia at the outpatient clinic. Children with rickets, other concurrent severe diseases, very severe pneumonia or wheeze, were excluded. Children were given vitamin D(3) or placebo drops additional to routine pneumonia treatment.
Results
Two hundred and twenty-four children received vitamin D(3;) and 229 received placebo. There was no significant difference in the mean number of days to recovery between the vitamin D(3) (4.74 days; SD 2.22) and placebo arms (4.98 days; SD 2.89; P = 0.17). The risk of a repeat episode of pneumonia within 90 days of supplementation was lower in the intervention (92/204; 45%) than the placebo group [122/211; (58%; relative risk 0.78; 95% CI 0.64, 0.94; P = 0.01]. Children in the vitamin D(3) group survived longer without experiencing a repeat episode (72 days vs. 59 days; HR 0.71; 95% CI 0.53-0.95; P = 0.02).
Conclusion
A single high-dose oral vitamin D(3) supplementation to young children along with antibiotic treatment for pneumonia could reduce the occurrence of repeat episodes of pneumonia.
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