Financiado en parte por U.S. Highbush Blueberry Council
Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women
Stull AJ, Cash KC, Johnson WD, Champagne CM, Cefalu WT
The Journal of nutrition · 258 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- Office of Dietary Supplements
- Grupo de la industria
- U.S. Highbush Blueberry Council
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Complementary and Alternative Medicine
- Gobierno
- National Center for Research Resources
- Gobierno
- National Center for Complementary and Integrative Health
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCCIH NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Institutes of Health (T32 A T004094); National Center for Complementary and Integrative Health (P50AT002776-01); National Institute of Diabetes and Digestive and Kidney Diseases (1P30DK072476); Office of Dietary Supplements (P50 AT002776); National Center for Complementary and Alternative Medicine (P50AT002776); National Center for Complementary and Alternative Medicine (P50AT002776‐01); National Center for Research Resources (P20 RR0-21945); National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK-072476); National Center for Complementary and Integrative Health (P50 AT002776); National Center for Complementary and Integrative Health (T32 A T004094); National Center for Complementary and Alternative Medicine (T32 A T004094); National Institutes of Health (NIH P20 RR021945); National Institutes of Health (P50AT002776); National Institutes of Health (P20RR021945); National Institutes of Health (DK072476); National Institutes of Health (NIH 1P30-DK072476); National Institutes of Health (1P30DK072476)
Según 10 financiadores declarados.
Publicación
- Publicado
- 2010-08-19 · J Nutr · vol. 140 · número 10 · págs. 1764–1768
- Editorial
- Elsevier BV
- Citado
- 395 citas · más que el 99% de estudios similares · 9.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 16 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Natural Antidiabetic Agents Studies · Adipokines, Inflammation, and Metabolic Diseases
- Palabras clave
- blueberry, dietary supplementation, insulin sensitivity, insulin resistance, obesity, hyperinsulinemic-euglycemic clamp, inflammatory markers, adiposity, non-diabetic adults
- MeSH
- humans, fruit, insulin resistance, obesity, inflammation, insulin, placebos, glucose clamp technique, phytotherapy, diet, double-blind method, energy intake, middle aged, diet records, female, male, adiposity, biomarkers, surveys and questionnaires, blueberry plants
5 autores
- April J. Stull🇺🇸Pennington Biomedical Research Center; Louisiana State University System
- Katherine C. Cash🇺🇸Pennington Biomedical Research Center; Louisiana State University System
- William D. Johnson🇺🇸Pennington Biomedical Research Center; Louisiana State University System
- Catherine M. Champagne🇺🇸Pennington Biomedical Research Center; Louisiana State University System
- William T. Cefalu🇺🇸 · autor de correspondenciaPennington Biomedical Research Center; Louisiana State University System
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary supplementation with whole blueberries in a preclinical study resulted in a reduction in glucose concentrations over time. We sought to evaluate the effect of daily dietary supplementation with bioactives from blueberries on whole-body insulin sensitivity in men and women. A double-blinded, randomized, and placebo-controlled clinical study design was used. After screening to resolve study eligibility, baseline (wk 0) insulin sensitivity was measured on 32 obese, nondiabetic, and insulin-resistant subjects using a high-dose hyperinsulinemic-euglycemic clamp (insulin infusion of 120 mU(861 pmol)⋅m(-2)⋅min(-1)). Serum inflammatory biomarkers and adiposity were measured at baseline. At the end of the study, insulin sensitivity, inflammatory biomarkers, and adiposity were reassessed. Participants were randomized to consume either a smoothie containing 22.5 g blueberry bioactives (blueberry group, n = 15) or a smoothie of equal nutritional value without added blueberry bioactives (placebo group, n = 17) twice daily for 6 wk. Both groups were instructed to maintain their body weight by reducing ad libitum intake by an amount equal to the energy intake of the smoothies. Participants' body weights were evaluated weekly and 3-d food records were collected at baseline, the middle, and end of the study. The mean change in insulin sensitivity improved more in the blueberry group (1.7 ± 0.5 mg⋅kg FFM(-1)⋅min(-1)) than in the placebo group (0.4 ± 0.4 mg⋅kg FFM(-1)⋅min(-1)) (P = 0.04). Insulin sensitivity was enhanced in the blueberry group at the end of the study without significant changes in adiposity, energy intake, and inflammatory biomarkers. In conclusion, daily dietary supplementation with bioactives from whole blueberries improved insulin sensitivity in obese, nondiabetic, and insulin-resistant participants.
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