Dietary intake of stearidonic acid-enriched soybean oil increases the omega-3 index: randomized, double-blind clinical study of efficacy and safety
Lemke SL, Vicini JL, Su H, Goldstein DA, Nemeth MA, Krul ES, Harris WS
The American journal of clinical nutrition · 83 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-08-26 · Am J Clin Nutr · vol. 92 · número 4 · págs. 766–775
- Editorial
- Elsevier BV
- Citado
- 118 citas · más que el 99% de estudios similares · 11.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 60 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Aquaculture Nutrition and Growth
- Palabras clave
- stearidonic acid, omega-3 index, soybean oil, eicosapentaenoic acid, docosahexaenoic acid, erythrocyte fatty acids, long-chain polyunsaturated fatty acids, cardiovascular risk markers, dietary supplementation, overweight adults
- MeSH
- erythrocytes, erythrocyte membrane, humans, fatty acids, omega-3, eicosapentaenoic acid, soybean oil, double-blind method, safety, patient selection, adult, aged, middle aged, female, male, overweight
7 autores
- Shawna L. Lemke
- John L. Vicini🇺🇸Monsanto (United States)
- Hong Lin Su🇺🇸Monsanto (United States)
- Daniel A. Goldstein🇺🇸Monsanto (United States)
- Margaret A. Nemeth🇺🇸Monsanto (United States)
- Elaine Susan Krul
- William Stephen Harris
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The benefits of omega-3 (n-3) long-chain polyunsaturated fatty acids to heart health are well established. Stearidonic acid (SDA, 18:4n-3) may contribute to these benefits.
Objective
The objective was to evaluate the ability of SDA-containing soybean oil to increase the omega-3 index [erythrocyte eicosapentaenoic acid (EPA) + docosahexaenoic acid, as a percentage of total fatty acids] and to affect other cardiovascular disease risk markers compared with EPA and regular soy oil (control).
Design
This was a randomized, placebo-controlled, double-blind multicenter study in which 252 overweight subjects were randomly assigned to 1 of 3 treatments for 12 wk: 1 g encapsulated soybean oil/d plus 14.7 g liquid soybean oil/d to be mixed in food (control group), 1 g encapsulated EPA/d plus 14.7 g liquid soybean oil/d (EPA group), and 1 g encapsulated soybean oil/d plus 14.7 g liquid SDA-enriched soybean oil/d, providing 4.2 g SDA (SDA group). Subjects consumed treatment oils in exchange for other oils in their diet.
Results
The mean (±SE) baseline omega-3 index was similar between treatments, but after 12 wk of treatment values for this index were 4.15 ± 0.12%, 4.84 ± 0.13%, and 4.69 ± 0.15% for control, EPA, and SDA groups, respectively. Values for the EPA and SDA groups were greater than those for control subjects in the intent-to-treat population (P < 0.001 and P = 0.006, respectively). No adverse treatment-related effects of SDA-enriched soybean oil were reported.
Conclusions
SDA-enriched soybean oil increased the omega-3 index by raising erythrocyte EPA concentrations. SDA-enriched soybean oil is a land-based n-3 fatty acid that is a sustainable approach to increasing tissue concentrations of long-chain polyunsaturated n-3 fatty acids.
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