Ingestion of broccoli sprouts does not improve endothelial function in humans with hypertension
Christiansen B, Bellostas Muguerza N, Petersen AM, Kveiborg B, Madsen CR, Thomas H, Ihlemann N, Sørensen JC, Køber L, Sørensen H, Torp-Pedersen C, Domínguez H
PloS one · 34 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Hjerteforeningen
- Organización sin fines de lucro
- Beckett-Fonden
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2010-08-27 · PLoS One · vol. 5 · número 8 · pág. e12461
- Editorial
- Public Library of Science
- Citado
- 43 citas · más que el 63% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 31 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Phytochemicals and Antioxidant Activities · Free Radicals and Antioxidants
- Palabras clave
- Blood pressure, Medicine, Ingestion, Endothelium, Diabetes mellitus, Oxidative stress, Essential hypertension, Internal medicine, Endocrinology, Physiology
- MeSH
- endothelium, vascular, humans, brassica, hypertension, glucosinolates, blood pressure, blood circulation, vasodilation, eating, adult, aged, middle aged, female, male
12 autores
- Buris Christiansen🇩🇰 · autor de correspondenciaHerlev Hospital; Copenhagen University Hospital; The Capital Region Pharmacy
- Natalia Bellostas Muguerza🇩🇰University of Copenhagen
- Atheline Major Petersen🇩🇰Odense University Hospital
- Britt Kveiborg🇩🇰Psychiatry Region Zealand
- Christian Rask Madsen🇺🇸Joslin Diabetes Center
- Hermann Thomas🇺🇸Joslin Diabetes Center
- Nikolaj Ihlemann🇩🇰Gentofte Hospital; Capital Region of Denmark
- Jens Christian Sørensen🇩🇰University of Copenhagen
- Lars Køber🇩🇰Gentofte Hospital; Capital Region of Denmark
- Hilmer Sørensen🇩🇰University of Copenhagen
- Christian Tobias Torp-Pedersen🇩🇰Gentofte Hospital; Capital Region of Denmark
- Helena Domínguez🇩🇰Herlev Hospital; Copenhagen University Hospital; Capital Region of Denmark
Resumen
El texto original del estudio, en el idioma en que se publicó.
Unlabelled
Ingestion of glucosinolates has previously been reported to improve endothelial function in spontaneously hypertensive rats, possibly because of an increase in NO availability in the endothelium due to an attenuation of oxidative stress; in our study we tried to see if this also would be the case in humans suffering from essential hypertension.
Methods
40 hypertensive individuals without diabetes and with normal levels of cholesterol were examined. The participants were randomized either to ingest 10 g dried broccoli sprouts, a natural donor of glucosinolates with high in vitro antioxidative potential, for a 4 week period or to continue their ordinary diet and act as controls. Blood pressure, endothelial function measured by flow mediated dilation (FMD) and blood samples were obtained from the participants every other week and the content of glucosinolates was measured before and after the study. Measurements were blinded to treatment allocation.
Results
In the interventional group overall FMD increased from 4% to 5.8% in the interventional group whereas in the control group FMD was stable (4% at baseline and 3.9% at the end of the study). The change in FMD in the interventional group was mainly due to a marked change in FMD in two participants while the other participants did not have marked changes in FMD. The observed differences were not statistically significant. Likewise significant changes in blood pressure or blood samples were not detected between or within groups. Diastolic blood pressure stayed essentially unchanged in both groups, while the systolic blood pressure showed a small non significant decrease (9 mm Hg) in the interventional group from a value of 153 mm Hg at start.
Conclusion
Daily ingestion of 10 g dried broccoli sprouts does not improve endothelial function in the presence of hypertension in humans.
Trial registration
Clinicaltrials.gov NCT00252018.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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