Dietary nitrate and nitrite and the risk of thyroid cancer in the NIH-AARP Diet and Health Study
Kilfoy BA, Zhang Y, Park Y, Holford TR, Schatzkin A, Hollenbeck A, Ward MH
International journal of cancer · 81 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Agriculture
- Gobierno
- National Institutes of Health
- Gobierno
- U.S. Geological Survey
- Gobierno
- National Cancer Institute
- Gobierno
- Intramural NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (TU2-CA-105666); National Institutes of Health (Z99 CA999999)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2010-09-08 · Int J Cancer · vol. 129 · número 1 · págs. 160–172
- Editorial
- Wiley
- Citado
- 145 citas · más que el 96% de estudios similares · 6.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · PUBLIC-DOMAIN
- Áreas de investigación
- Nutritional Studies and Diet · Thyroid Cancer Diagnosis and Treatment · Thyroid Disorders and Treatments
- Palabras clave
- Nitrite, Nitrate, Medicine, Thyroid cancer, Dietary Nitrate, Cancer, Environmental health, Internal medicine, Physiology, Endocrinology, Biology
- MeSH
- humans, thyroid neoplasms, nitrates, nitrites, diet, risk factors, prospective studies, middle aged, diet records, female, male, surveys and questionnaires
7 autores
- Briseis A. Kilfoy🇺🇸 · autor de correspondenciaNational Institutes of Health; Yale University; In-Q-Tel; National Cancer Institute; Department of Health and Human Services
- Yawei Zhang🇺🇸Yale University
- Yikyung Park🇺🇸National Institutes of Health; National Cancer Institute
- Theodore R. Holford🇺🇸Yale University
- Arthur G. Schatzkin🇺🇸National Institutes of Health; National Cancer Institute
- Albert R. Hollenbeck🇺🇸AARP
- Mary H. Ward🇺🇸National Institutes of Health; National Cancer Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
During the past several decades, an increasing incidence of thyroid cancer has been observed worldwide. Nitrate inhibits iodide uptake by the thyroid, potentially disrupting thyroid function. An increased risk of thyroid cancer associated with nitrate intake was recently reported in a cohort study of older women in Iowa. We evaluated dietary nitrate and nitrite intake and thyroid cancer risk overall and for subtypes in the National Institutes of Health-American Association of Retired Persons (NIH-AARP) Diet and Health Study, a large prospective cohort of 490,194 men and women, ages 50-71 years in 1995-1996. Dietary intakes were assessed using a 124-item food frequency questionnaire. During an average of 7 years of follow-up we identified 370 incident thyroid cancer cases (170 men, 200 women) with complete dietary information. Among men, increasing nitrate intake was positively associated with thyroid cancer risk (relative risk [RR] for the highest quintile versus lowest quintile RR = 2.28, 95% confidence interval [CI]: 1.29-4.041; p-trend <0.001); however, we observed no trend with intake among women (p-trend = 0.61). Nitrite intake was not associated with risk of thyroid cancer for either men or women. We evaluated risk for the two main types of thyroid cancer. We found positive associations for nitrate intake and both papillary (RR = 2.10; 95% CI: 1.09-4.05; p-trend = 0.05) and follicular thyroid cancer (RR = 3.42; 95% CI: 1.03-11.4; p-trend = 0.01) among men. Nitrite intake was associated with increased risk of follicular thyroid cancer (RR = 2.74; 95%CI: 0.86-8.77; p-trend = 0.04) among men. Our results support a role of nitrate in thyroid cancer risk and suggest that further studies to investigate these exposures are warranted.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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