Financiado en parte por Almond Board of California
Almond consumption and cardiovascular risk factors in adults with prediabetes
Wien M, Bleich D, Raghuwanshi M, Gould-Forgerite S, Gomes J, Monahan-Couch L, Oda K
Journal of the American College of Nutrition · 90 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Organización sin fines de lucro
- American Diabetes Association
- Gobierno
- U.S. Department of Agriculture
- Grupo de la industria
- Almond Board of California
Según 3 financiadores declarados.
Publicación
- Publicado
- 2010-06-01 · J Am Coll Nutr · vol. 29 · número 3 · págs. 189–197
- Editorial
- Taylor & Francis
- Citado
- 129 citas · más que el 91% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- almond consumption, prediabetes, insulin sensitivity, insulin resistance, beta-cell function, LDL cholesterol, cardiovascular risk factors, dietary intervention, HbA1c, blood pressure
- MeSH
- humans, prunus, nuts, cardiovascular diseases, prediabetic state, insulin resistance, insulin, plant preparations, phytotherapy, risk factors, adult, aged, middle aged, female, male, insulin-secreting cells, cholesterol, ldl
7 autores
- Michelle Wien · autor de correspondencia
- David Bleich🇺🇸Rutgers New Jersey Medical School
- Maya P. Raghuwanshi🇺🇸Rutgers New Jersey Medical School
- Susan Gould-Forgerite🇺🇸Rutgers New Jersey Medical School
- Jacqueline Gomes🇺🇸Rutgers New Jersey Medical School
- Lynn Monahan Couch🇺🇸West Chester University
- Keiji Oda🇺🇸Loma Linda University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The authors tested the hypothesis that in adults with prediabetes, an almond-enriched American Diabetes Association (ADA) diet improves measures of insulin sensitivity and other cardiovascular risk factors compared with an ADA nut-free diet.
Design
Randomized parallel-group trial.
Setting
Outpatient dietary counseling and blood analysis.
Subjects
Sixty-five adult participants with prediabetes.
Intervention
Sixteen weeks of dietary modification featuring an ADA diet containing 20% of energy from almonds (approximately 2 oz per day).
Measures of outcome
Outcomes included fasting glucose, insulin, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, TC:HDL-C, and HbA1c, which were measured at weeks 0, 8, and 16. Body weight, body mass index (BMI), waist circumference, blood pressure, and nutrient intake were measured at weeks 0, 4, 8, 12, and 16.
Results
The almond-enriched intervention group exhibited greater reductions in insulin (-1.78 µU/ml vs. +1.47 µU/ml, p = 0.002), homeostasis model analysis for insulin resistance (-0.48 vs. +0.30, p = 0.007), and homeostasis model analysis for beta-cell function (-13.2 vs. +22.3, p = 0.001) compared with the nut-free control group. Clinically significant declines in LDL-C were found in the almond-enriched intervention group (-12.4 mg/dl vs. -0.4 mg/dl) as compared with the nut-free control group. No changes were observed in BMI (-0.4 vs. -0.7 kg/m(2), p = 0.191), systolic blood pressure (-4.4 mm Hg vs. -3.5 mm Hg, p = 0.773), or for the other measured cardiovascular risk factors.
Conclusions
An ADA diet consisting of 20% of calories as almonds over a 16-week period is effective in improving markers of insulin sensitivity and yields clinically significant improvements in LDL-C in adults with prediabetes.
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