Creatine in type 2 diabetes: a randomized, double-blind, placebo-controlled trial
Gualano B, DE Salles Painneli V, Roschel H, Artioli GG, Neves M, De Sá Pinto AL, Da Silva ME, Cunha MR, Otaduy MC, Leite Cda C, Ferreira JC, Pereira RM, Brum PC, Bonfá E, Lancha AH
Medicine and science in sports and exercise · 75 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-09-29 · Med Sci Sports Exerc · vol. 43 · número 5 · págs. 770–778
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 99 citas · más que el 81% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Diabetes Management and Research · Natural Antidiabetic Agents Studies
- Palabras clave
- creatine supplementation, type 2 diabetes, glycemic control, exercise training, HbA1c, insulin sensitivity, GLUT4 translocation, glucose tolerance, insulin, C-peptide
- MeSH
- humans, diabetes mellitus, type 2, creatine, blood glucose, lipids, phosphocreatine, blotting, western, exercise, double-blind method, oxygen consumption, energy intake, dietary supplements, middle aged, female, male, glycated hemoglobin
15 autores
- Bruno Gualano🇧🇷Universidade de São Paulo
- VITOR DE SALLES PAINNELI🇧🇷Universidade de São Paulo
- Hamilton Roschel🇧🇷Universidade de São Paulo
- Guilherme Giannini Artioli🇧🇷Universidade de São Paulo
- Manoel Neves🇧🇷Universidade de São Paulo
- Ana Lúcia de Sá Pinto🇧🇷Universidade de São Paulo
- Maria Elizabeth Rossi da Silva🇧🇷Universidade de São Paulo
- Maria Rosária Cunha🇧🇷Universidade de São Paulo
- Maria Concepción García Otaduy🇧🇷Universidade de São Paulo
- Cláudia da Costa Leite🇧🇷Universidade de São Paulo
- Julio Cesar Batista Ferreira🇧🇷Universidade de São Paulo
- Rosa Maria Rodrigues Pereira🇧🇷Universidade de São Paulo
- Patrı́cia C. Brum🇧🇷Universidade de São Paulo
- Eloísa Bonfá🇧🇷Universidade de São Paulo
- Antônio Herbert Lancha🇧🇷Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Unlabelled
Creatine supplementation improves glucose tolerance in healthy subjects.
Purposes
The aim was to investigate whether creatine supplementation has a beneficial effect on glycemic control of type 2 diabetic patients undergoing exercise training.
Methods
A 12-wk randomized, double-blind, placebo-controlled trial was performed. The patients were allocated to receive either creatine (CR) (5 g·d) or placebo (PL) and were enrolled in an exercise training program. The primary outcome was glycosylated hemoglobin (HbA1c). Secondary outcomes included the area under the curve of glucose, insulin, and C-peptide and insulin sensitivity indexes. Physical capacity, lipid profile, and GLUT-4 protein expression and translocation were also assessed.
Results
Twenty-five subjects were analyzed (CR: n=13; PL: n=12). HbA1c was significantly reduced in the creatine group when compared with the placebo group (CR: PRE=7.4 ± 0.7, POST=6.4 ± 0.4; PL: PRE=7.5 ± 0.6, POST=7.6 ± 0.7; P=0.004; difference=-1.1%, 95% confidence interval=-1.9% to -0.4%). The delta area under the curve of glucose concentration was significantly lower in the CR group than in the PL group (CR=-7790 ± 4600, PL=2008 ± 7614; P=0.05). The CR group also presented decreased glycemia at times 0, 30, and 60 min during a meal tolerance test and increased GLUT-4 translocation. Insulin and C-peptide concentrations, surrogates of insulin sensitivity, physical capacity, lipid profile, and adverse effects were comparable between the groups.
Conclusions
Creatine supplementation combined with an exercise program improves glycemic control in type 2 diabetic patients. The underlying mechanism seems to be related to an increase in GLUT-4 recruitment to the sarcolemma.
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