Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis
Stockton KA, Mengersen K, Paratz JD, Kandiah D, Bennell KL
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 279 citas
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Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-10-05 · Osteoporos Int · vol. 22 · número 3 · págs. 859–71
- Editorial
- Springer Science+Business Media
- Citado
- 419 citas · más que el 91% de estudios similares · 2.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Nutrition and Health in Aging
- Palabras clave
- vitamin D supplementation, muscle strength, vitamin D deficiency, 25-hydroxyvitamin D, grip strength, hip muscle strength, calcium supplementation, adults
- MeSH
- lower extremity, humans, vitamin d deficiency, calcium, dietary, hydroxycholecalciferols, hand strength, treatment outcome, dietary supplements, adult, aged, aged, 80 and over, middle aged, female, male, bone density conservation agents, muscle strength, randomized controlled trials as topic
5 autores
- Kellie A. Stockton🇦🇺 · autor de correspondenciaThe University of Queensland; Royal Brisbane and Women's Hospital
- Kerrie Lee Mengersen🇦🇺Queensland University of Technology
- Jennifer Davida Paratz🇦🇺The University of Queensland
- David A. Kandiah🇦🇺The University of Queensland
- Kim Louise Bennell🇦🇺The University of Melbourne
Resumen
El texto original del estudio, en el idioma en que se publicó.
Unlabelled
This systematic review demonstrates that vitamin D supplementation does not have a significant effect on muscle strength in vitamin D replete adults. However, a limited number of studies demonstrate an increase in proximal muscle strength in adults with vitamin D deficiency.
Introduction
The purpose of this study is to systematically review the evidence on the effect of vitamin D supplementation on muscle strength in adults.
Methods
A comprehensive systematic database search was performed. Inclusion criteria included randomised controlled trials (RCTs) involving adult human participants. All forms and doses of vitamin D supplementation with or without calcium supplementation were included compared with placebo or standard care. Outcome measures included evaluation of strength. Outcomes were compared by calculating standardised mean difference (SMD) and 95% confidence intervals.
Results
Of 52 identified studies, 17 RCTs involving 5,072 participants met the inclusion criteria. Meta-analysis showed no significant effect of vitamin D supplementation on grip strength (SMD -0.02, 95%CI -0.15,0.11) or proximal lower limb strength (SMD 0.1, 95%CI -0.01,0.22) in adults with 25(OH)D levels > 25 nmol/L. Pooled data from two studies in vitamin D deficient participants (25(OH)D <25 nmol/L) demonstrated a large effect of vitamin D supplementation on hip muscle strength (SMD 3.52, 95%CI 2.18, 4.85).
Conclusion
Based on studies included in this systematic review, vitamin D supplementation does not have a significant effect on muscle strength in adults with baseline 25(OH)D >25 nmol/L. However, a limited number of studies demonstrate an increase in proximal muscle strength in adults with vitamin D deficiency.
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