The effect of low-level laser therapy as an adjunct to non-surgical periodontal treatment
Aykol G, Baser U, Maden I, Kazak Z, Onan U, Tanrikulu-Kucuk S, Ademoglu E, Issever H, Yalcin F
Journal of periodontology · 83 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Istanbul Üniversitesi
- Subvenciones
- Istanbul Üniversitesi (T‐969/06102006)
Según 1 financiador declarado.
Publicación
- Publicado
- 2010-10-08 · J Periodontol · vol. 82 · número 3 · págs. 481–488
- Editorial
- Wiley
- Citado
- 136 citas · más que el 96% de estudios similares · 5.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Oral microbiology and periodontitis research · Periodontal Regeneration and Treatments
- Palabras clave
- low-level laser therapy, adjunctive periodontal therapy, chronic periodontitis, smoking, GaAlAs laser, 808 nm laser, gingival crevicular fluid, MMP-1, TIMP-1, TGF-β1, basic fibroblast growth factor, clinical attachment level, probing depth
- MeSH
- gingival crevicular fluid, humans, fibroblast growth factor 2, tissue inhibitor of metalloproteinase-1, radiotherapy, adjuvant, periodontal index, statistics, nonparametric, dental scaling, smoking, wound healing, adult, middle aged, female, male, transforming growth factor beta1, matrix metalloproteinase 1, lasers, semiconductor, chronic periodontitis, low-level light therapy
9 autores
- Gokce Aykol🇹🇷Istanbul University
- Ülkü Başer🇹🇷 · autor de correspondenciaIstanbul University
- Ilay Maden🇹🇷Istanbul University
- Zafer Kazak
- Utku Onan🇹🇷Istanbul University
- Sevda Tanrıkulu-Küçük🇹🇷Istanbul University
- Evin Ademoğlu🇹🇷Istanbul University
- Halim İşsever🇹🇷Istanbul University
- Funda Yalçın🇹🇷Istanbul University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The aim of this study is to evaluate the effect of low-level laser therapy (LLLT) as an adjunct to non-surgical periodontal therapy of smoking and non-smoking patients with moderate to advanced chronic periodontitis.
Methods
All 36 systemically healthy patients who were included in the study initially received non-surgical periodontal therapy. The LLLT group (n = 18) received GaAlAs diode laser therapy as an adjunct to non-surgical periodontal therapy. A diode laser with a wavelength of 808 nm was used for the LLLT. Energy density of 4 J/cm(2) was applied to the gingival surface after periodontal treatment on the first, second, and seventh days. Each of the LLLT and control groups was divided into two groups as smoking and non-smoking patients to investigate the effect of smoking on treatment. Gingival crevicular fluid samples were collected from all patients and clinical parameters were recorded on baseline, the first, third, and sixth months after treatment. Matrix metalloproteinase-1, tissue inhibitor matrix metalloproteinase-1, transforming growth factor-β1, and basic-fibroblast growth factor levels in the collected gingival crevicular fluid were measured.
Results
The primary outcome variable in this study was change in gingival bleeding and inflammation. At all time points, the LLLT group showed significantly more improvement in sulcus bleeding index (SBI), clinical attachment level, and probing depth (PD) levels compared to the control group (P <0.001). There were clinically significant improvements in the laser-applied smokers' PD and SBI levels compared to smokers to whom a laser was not applied, between the baseline and all time points (P <0.001) (SBI score: control group 1.12, LLLT group 1.49; PD: control group 1.21 mm, LLLT group 1.46 mm, between baseline and 6 months). Transforming growth factor-β1 levels and the ratio of matrix metalloproteinase-1 to tissue inhibitor matrix metalloproteinase-1 decreased significantly in both groups at 1, 3, and 6 months after periodontal therapy (P <0.001). Basic-fibroblast growth factor levels significantly decreased in both groups in the first month after the treatment, then increased in the third and sixth months (P <0.005). No marker level change showed significant differences between the groups (P <0.05).
Conclusion
LLLT as an adjunctive therapy to non-surgical periodontal treatment improves periodontal healing.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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