Caffeine protects against increased risk-taking propensity during severe sleep deprivation
Killgore WD, Kamimori GH, Balkin TJ
Journal of sleep research · 50 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-10-14 · J Sleep Res · vol. 20 · número 3 · págs. 395–403
- Editorial
- Wiley
- Citado
- 90 citas · más que el 95% de estudios similares · 6.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Sleep and Work-Related Fatigue · Coffee research and impacts · Sleep and Wakefulness Research
- Palabras clave
- caffeine, sleep deprivation, risk-taking, Balloon Analogue Risk Task, impulsivity, cost-benefit decision making, prolonged wakefulness
- MeSH
- brain, humans, sleep deprivation, caffeine, central nervous system stimulants, risk-taking, neuropsychological tests, adult, female, male, young adult
3 autores
- William D. S. Killgore🇺🇸 · autor de correspondenciaWalter Reed Army Institute of Research
- Gary H. Kamimori🇺🇸Walter Reed Army Institute of Research
- Thomas J. Balkin🇺🇸Walter Reed Army Institute of Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Previous research suggests that sleep deprivation is associated with declines in metabolic activity within brain regions important for judgement and impulse control, yet previous studies have reported inconsistent findings regarding the effects of sleep loss and caffeine on risk-taking. In this study, 25 healthy adults (21 men, four women) completed the Balloon Analog Risk Task (BART) and Evaluation of Risks (EVAR) scale at regular intervals to examine behavioral and self-reported risk-taking propensity during 75 h of continuous sleep deprivation. Participants received either four double-blind administrations of 200 mg caffeine (n=12) or indistinguishable placebo (n=13) gum bi-hourly during each of the 3 nights of sleep deprivation. No significant effects of drug group or sleep deprivation were evident on the BART or EVAR when measured at 51 h of wakefulness. However, by 75 h, the placebo group showed a significant increase in risk-taking behavior on the cost-benefit ratio and total number of exploded balloons on the BART, whereas the caffeine group remained at baseline levels. On the EVAR, several factors of self-reported risk-taking propensity, including total risk, impulsivity and risk/thrill seeking, were reduced among subjects receiving caffeine across the 3 days of sleep deprivation, but remained at baseline levels for the placebo group. These results suggest that 3 nights of total sleep deprivation led to a significant increase in behavioral risk-taking but not self-reported perception of risk-propensity. Overnight caffeine prevented this increase in risky behavior.
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