Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial
Gualano B, de Salles Painelli V, Roschel H, Lugaresi R, Dorea E, Artioli GG, Lima FR, da Silva ME, Cunha MR, Seguro AC, Shimizu MH, Otaduy MC, Sapienza MT, da Costa Leite C, Bonfá E, Lancha Junior AH
European journal of applied physiology · 54 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
Según 1 financiador declarado.
Publicación
- Publicado
- 2010-10-25 · Eur J Appl Physiol · vol. 111 · número 5 · págs. 749–756
- Editorial
- Springer Science+Business Media
- Citado
- 88 citas · más que el 84% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 28 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Chronic Kidney Disease and Diabetes · Dialysis and Renal Disease Management
- Palabras clave
- creatine supplementation, type 2 diabetes, renal function, renal safety, 51Cr-EDTA clearance, creatinine clearance, muscle creatine, exercise training, albuminuria, proteinuria, electrolytes
- MeSH
- kidney, humans, diabetes mellitus, type 2, creatine, kidney function tests, double-blind method, dietary supplements, middle aged, female, male
16 autores
- Bruno Gualano🇧🇷 · autor de correspondenciaUniversidade de São Paulo
- Vítor de Salles Painelli🇧🇷Universidade de São Paulo
- Hamilton Roschel🇧🇷Universidade de São Paulo
- Rebeca Lugaresi🇧🇷Universidade de São Paulo
- Egı́dio Lima Dórea🇧🇷Universidade de São Paulo; Hospital Universitário da Universidade de São Paulo
- Guilherme Giannini Artioli🇧🇷Universidade de São Paulo
- Fernanda Rodrigues Lima🇧🇷Universidade de São Paulo
- Maria Elizabeth Rossi da Silva🇧🇷Universidade de São Paulo
- Maria Rosária Cunha🇧🇷Universidade de São Paulo
- Antônio Carlos Seguro🇧🇷Universidade de São Paulo
- Maria Heloísa Massola Shimizu🇧🇷Universidade de São Paulo
- Maria Concepción García Otaduy🇧🇷Universidade de São Paulo
- Marcelo Tatit Sapienza🇧🇷Universidade de São Paulo
- Cláudia da Costa Leite🇧🇷Universidade de São Paulo
- Eloísa Bonfá🇧🇷Universidade de São Paulo
- Antônio Herbert Lancha🇧🇷Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Creatine supplementation may have a therapeutic role in diabetes, but it is uncertain whether this supplement is safe for kidney function. The aim of this study was to investigate the effects of creatine supplementation on kidney function in type 2 diabetic patients. A randomized, double-blind, placebo-controlled trial was performed. The patients were randomly allocated to receive either creatine or placebo for 12 weeks. All the patients underwent exercise training throughout the trial. Subjects were assessed at baseline and after the intervention. Blood samples and 24-h urine samples were obtained for kidney function assessments. Additionally, (51)Cr-EDTA clearance was performed. To ensure the compliance with creatine intake, we also assessed muscle phosphorylcreatine content. The creatine group presented higher muscle phosphorylcreatine content when compared to placebo group (CR Pre 44 ± 10, Post 70 ± 18 mmol/kg/wt; PL Pre 52 ± 13, Post 46 ± 13 mmol/kg/wt; p = 0.03; estimated difference between means 23.6; 95% confidence interval 1.42-45.8). No significant differences were observed for (51)Cr-EDTA clearance (CR Pre 90.4 ± 16.9, Post 96.1 ± 15.0 mL/min/1.73 m(2); PL Pre 97.9 ± 21.6, Post 96.4 ± 26.8 mL/min/1.73 m(2); p = 0.58; estimated difference between means -0.3; 95% confidence interval -24.9 to 24.2). Creatinine clearance, serum and urinary urea, electrolytes, proteinuria, and albuminuria were unchanged. CR supplementation does not affect kidney function in type 2 diabetic patients, opening a window of opportunities to explore its promising therapeutic role in this population. ClinicalTrials.gov registration number: NCT00992043.
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