Dietary omega-3 fatty acids and fish consumption and risk of type 2 diabetes
Djoussé L, Gaziano JM, Buring JE, Lee IM
The American journal of clinical nutrition · 124 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Cancer Institute
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (HL043851); National Cancer Institute (R01CA097193); National Cancer Institute (CA 047988); National Heart, Lung, and Blood Institute (HL080467)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2010-10-28 · Am J Clin Nutr · vol. 93 · número 1 · págs. 143–150
- Editorial
- Elsevier BV
- Citado
- 183 citas · más que el 99% de estudios similares · 17.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Diet, Metabolism, and Disease
- Palabras clave
- omega-3 fatty acids, fish consumption, type 2 diabetes, docosahexaenoic acid, long-chain polyunsaturated fatty acids, dietary intake, women, hypertension, Women's Health Study
- MeSH
- animals, fishes, humans, diabetes mellitus, type 2, fatty acids, omega-3, diet, prospective studies, double-blind method, middle aged, women's health, female
4 autores
- Luc Djoussé🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University; VA Boston Healthcare System
- J. Michael Gaziano🇺🇸Brigham and Women's Hospital; Harvard University; VA Boston Healthcare System
- Julie E. Buring🇺🇸Brigham and Women's Hospital; Harvard University; VA Boston Healthcare System
- I‐Min Lee🇺🇸Brigham and Women's Hospital; Harvard University; VA Boston Healthcare System
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Although dietary omega-3 (n-3) fatty acids may confer some cardiovascular benefits, it is unclear whether these nutrients may also unfavorably affect risk of type 2 diabetes (T2D).
Objective
We evaluated whether dietary omega-3 fatty acids and fish consumption were associated with increased risk of T2D.
Design
This was a prospective study of 36,328 women (mean age: 54.6 y) who participated in the Women's Health Study and who were followed from 1992 to 2008. Incident T2D was self-reported and validated primarily through the collection of supplementary information from participants. Information on omega-3 and fish intakes was obtained by using a validated food-frequency questionnaire. We used Cox proportional hazard models to estimate adjusted relative risks.
Results
During an average follow-up of 12.4 y, 2370 women developed T2D. Marine but not plant-based omega-3 fatty acids were positively associated with incident T2D. From the lowest to highest quintiles of marine omega-3 intake, the multivariable-adjusted hazard ratios (95% CIs) for T2D were 1.0 (referent), 1.17 (1.03, 1.33), 1.20 (1.05, 1.38), 1.46 (1.28, 1.66), and 1.44 (1.25, 1.65), respectively (P for trend < 0.0001). A similar association was observed with fish intake, but additional adjustment for docosahexaenoic acid led to the elimination of the association. The relation between marine omega-3 fatty acids and T2D was observed in hypertensive and nonhypertensive subjects and in women who reported infrequent fish consumption.
Conclusion
Our data suggest an increased risk of T2D with the intake of long-chain omega-3 fatty acids, especially with higher intakes (≥ 0.20 g omega-3/d or ≥ 2 servings of fish/d). The Women's Health Study was registered at clinicaltrials.gov as NCT00000479.
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