Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women
Goto A, Song Y, Chen BH, Manson JE, Buring JE, Liu S
Diabetes · 50 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
- Empresa
- Burroughs Wellcome Fund
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Human Genome Research Institute
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCI NIH HHS
- Gobierno
- NHGRI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (HL043851); National Heart, Lung, and Blood Institute (R01‐HL043851); National Human Genome Research Institute (T32‐HG002536); National Institute of Diabetes and Digestive and Kidney Diseases (K01 DK078846); National Institute of Diabetes and Digestive and Kidney Diseases (DK066401); National Heart, Lung, and Blood Institute (R01 HL080467); National Cancer Institute (CA 047988); National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK066401); National Heart, Lung, and Blood Institute (HL080467); National Cancer Institute (R01CA047988)
Según 9 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2010-10-28 · Diabetes · vol. 60 · número 1 · págs. 269–275
- Editorial
- American Diabetes Association
- Citado
- 78 citas · más que el 97% de estudios similares · 5.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 29 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Coffee research and impacts · Nutritional Studies and Diet · Alcohol Consumption and Health Effects
- Palabras clave
- coffee consumption, caffeine, sex hormone-binding globulin, type 2 diabetes, postmenopausal women, sex hormones, decaffeinated coffee, tea, Women's Health Study
- MeSH
- humans, diabetes mellitus, type 2, caffeine, gonadal steroid hormones, sex hormone-binding globulin, diet, multivariate analysis, odds ratio, double-blind method, feeding behavior, postmenopause, beverages, coffee, aged, middle aged, female, surveys and questionnaires
6 autores
- Atsushi Goto🇺🇸University of California, Los Angeles
- Yiqing Song🇺🇸Brigham and Women's Hospital; Harvard University
- Brian H. Chen🇺🇸University of California, Los Angeles
- JoAnn E. Manson🇺🇸Brigham and Women's Hospital; Harvard University
- Julie E. Buring🇺🇸Brigham and Women's Hospital; Harvard University
- Simin Liu🇺🇸 · autor de correspondenciaUniversity of California, Los Angeles; UCLA Jonsson Comprehensive Cancer Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Coffee consumption has been inversely associated with type 2 diabetes risk, but its mechanisms are largely unknown. We aimed to examine whether plasma levels of sex hormones and sex hormone-binding globulin (SHBG) may account for the inverse association between coffee consumption and type 2 diabetes risk.
Research design and methods
We conducted a case-control study nested in the prospective Women's Health Study (WHS). During a median follow-up of 10 years, 359 postmenopausal women with newly diagnosed type 2 diabetes were matched with 359 control subjects by age, race, duration of follow-up, and time of blood draw.
Results
Caffeinated coffee was positively associated with SHBG but not with sex hormones. Multivariable-adjusted geometric mean levels of SHBG were 26.6 nmol/l among women consuming ≥4 cups/day of caffeinated coffee and 23.0 nmol/l among nondrinkers (P for trend = 0.01). In contrast, neither decaffeinated coffee nor tea was associated with SHBG or sex hormones. The multivariable-adjusted odds ratio (OR) of type 2 diabetes for women consuming ≥4 cups/day of caffeinated coffee compared with nondrinkers was 0.47 (95% CI 0.23-0.94; P for trend = 0.047). The association was largely attenuated after further adjusting for SHBG (OR 0.71 [95% CI 0.31-1.61]; P for trend = 0.47). In addition, carriers of rs6259 minor allele and noncarriers of rs6257 minor allele of SHBG gene consuming ≥2 cups/day of caffeinated coffee had lower risk of type 2 diabetes in directions corresponding to their associated SHBG.
Conclusions
Our findings suggest that SHBG may account for the inverse association between coffee consumption and type 2 diabetes risk among postmenopausal women.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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