Pilot, prospective, randomized, double-masked, placebo-controlled clinical trial of an omega-3 supplement for dry eye
Wojtowicz JC, Butovich I, Uchiyama E, Aronowicz J, Agee S, McCulley JP
Cornea · 101 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Eye Institute
- Gobierno
- NEI NIH HHS
- Subvenciones
- National Eye Institute (EY-016664); National Eye Institute (EY12430)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2010-11-01 · Cornea · vol. 30 · número 3 · págs. 308–314
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 148 citas · más que el 99% de estudios similares · 10.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- De pago
- Áreas de investigación
- Ocular Surface and Contact Lens · Fatty Acid Research and Health · Salivary Gland Disorders and Functions
- Palabras clave
- dry eye, omega-3 fatty acids, fish oil supplementation, eicosapentaenoic acid, docosahexaenoic acid, linseed oil, tear secretion, tear volume, Schirmer test, fluorescence spectroscopy, meibomian glands, ocular surface disease
- MeSH
- meibomian glands, tears, humans, dry eye syndromes, lipids, fatty acids, omega-3, capsules, fluorophotometry, chromatography, high pressure liquid, spectrometry, mass, electrospray ionization, prospective studies, pilot projects, double-blind method, dietary supplements, adult, aged, aged, 80 and over, middle aged, diet records, female, male, lipid metabolism, surveys and questionnaires
6 autores
- Jadwiga Cristina Wojtowicz🇺🇸The University of Texas Southwestern Medical Center
- Igor A. Butovich🇺🇸The University of Texas Southwestern Medical Center
- Eduardo Uchiyama🇺🇸The University of Texas Southwestern Medical Center
- Joel D. Aronowicz🇺🇸The University of Texas Southwestern Medical Center
- Shawn Agee🇺🇸The University of Texas Southwestern Medical Center
- James P. McCulley🇺🇸The University of Texas Southwestern Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To investigate the potential effect of dietary supplementation with omega-3 fatty acid on lipid composition of meibum, aqueous tear evaporation, and tear volume in patients with dry eye.
Methods
In a pilot, prospective, randomized, double-masked study, patients with dry eye received a daily dose of fish oil, containing 450 mg of eicosapentaenoic acid, 300 mg of docosahexaenoic acid, and 1000 mg of flaxseed oil (TheraTears Nutrition; Advanced Vision Research, Woburn, MA) for 90 days. There were 2 patient visits: baseline and final. At these visits, patients completed the ocular surface disease index to score subjective symptoms, and slit-lamp examinations, breakup time, corneal staining, Schirmer type I, fluorophotometry, evaporometry, and collection of meibomian gland secretion samples for lipid composition analysis were performed.
Results
A total of 36 patients with dry eye completed the study. At the end of the study, 70% of the patients became asymptomatic, whereas for the placebo group, 37% [corrected] of the symptomatic patients became asymptomatic. Schirmer testing and fluorophotometry suggested that the omega-3 supplement increased tear secretion. The lipid composition of the samples collected from the omega-3 group was found to be very similar to that from the placebo group. No trends between groups were seen for other objective parameters.
Conclusions
Dietary supplementation with omega-3 fatty acids in dry eye showed no significant effect in meibum lipid composition or aqueous tear evaporation rate. On the other hand, the average tear production and tear volume was increased in the omega-3 group as indicated by both Schirmer testing and fluorophotometry.
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