Financiado en parte por Pharmavite
Does vitamin D affect risk of developing autoimmune disease?: a systematic review
Kriegel MA, Manson JE, Costenbader KH
Seminars in arthritis and rheumatism · 117 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Brigham and Women's Hospital
- Empresa
- Pharmavite
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Gobierno
- NIAMS NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Institutes of Health (OmegA-3 TriaL); National Cancer Institute (5U01CA138962); National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR059086)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2010-11-03 · Semin Arthritis Rheum · vol. 40 · número 6 · págs. 512–531.e8
- Editorial
- Elsevier BV
- Citado
- 192 citas · más que el 75% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 241 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Psoriasis: Treatment and Pathogenesis · Systemic Lupus Erythematosus Research
- Palabras clave
- vitamin D, autoimmune disease, autoimmune disease susceptibility, vitamin D supplementation, VDR polymorphisms, innate and adaptive immunity, autoimmune disease prevention, vitamin D intake, vitamin D levels
- MeSH
- immune system, animals, humans, autoimmune diseases, vitamin d, receptors, calcitriol, risk factors, cross-sectional studies, polymorphism, genetic, pubmed, immunity, innate, adaptive immunity
3 autores
- Martin Alexander Kriegel🇺🇸Brigham and Women's Hospital; Harvard University
- JoAnn E. Manson🇺🇸Brigham and Women's Hospital; Harvard University
- Karen H. Costenbader🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
We evaluated the epidemiologic evidence that vitamin D may be related to human autoimmune disease risk.
Methods
PubMed, limited to English from inception through April 2010, was searched using keywords: "vitamin D," "autoimmune," and autoimmune disease names. We summarized in vitro, animal, and genetic association studies of vitamin D in autoimmune disease pathogenesis. We sorted epidemiologic studies by design and disease and performed a systematic review of (a) cross-sectional data concerning vitamin D level and autoimmune disease; (b) interventional data on vitamin D supplementation in autoimmune diseases; and (c) prospective data linking vitamin D level or intake to autoimmune disease risk.
Results
Vitamin D has effects on innate and acquired immune systems, and vitamin D receptor polymorphisms have been associated with various autoimmune diseases. In experimental animal models, vitamin D supplementation can prevent or forestall autoimmune disease. Of 1446 studies identified and screened, 76 studies examined vitamin D levels in autoimmune disease patients, particularly with active disease, and compared with controls. Nineteen observational or interventional studies assessed the effect of vitamin D supplementation as therapy for various autoimmune diseases (excluding psoriasis and vitiligo) with a range of study approaches and results. The few prospective human studies performed conflict as to whether vitamin D level or intake is associated with autoimmune disease risk. No interventional trials have investigated whether vitamin D affects human autoimmune disease risk.
Conclusions
Cross-sectional data point to a potential role of vitamin D in autoimmune disease prevention, but prospective interventional evidence in humans is still lacking.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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