A randomized controlled trial of the effects of vitamin D on muscle strength and mobility in older women with vitamin D insufficiency
Zhu K, Austin N, Devine A, Bruce D, Prince RL
Journal of the American Geriatrics Society · 107 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Health and Medical Research Council
- Gobierno
- National Medical Research Council
Según 2 financiadores declarados.
Publicación
- Publicado
- 2010-11-01 · J Am Geriatr Soc · vol. 58 · número 11 · págs. 2063–2068
- Editorial
- Wiley
- Citado
- 176 citas · más que el 98% de estudios similares · 7.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 22 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health in Aging · Bone health and osteoporosis research
- Palabras clave
- vitamin D supplementation, vitamin D insufficiency, muscle strength, mobility (physical function), older women, 25-hydroxyvitamin D, hip extensors, hip adductors, Timed Up and Go test, calcium citrate, community-dwelling older adults
- MeSH
- humans, vitamin d deficiency, vitamins, vitamin d, double-blind method, aged, aged, 80 and over, female, mobility limitation, muscle strength
5 autores
- Kun Zhu🇦🇺Edith Cowan University; The University of Western Australia; Sir Charles Gairdner Hospital
- Nicole Austin🇦🇺Edith Cowan University; The University of Western Australia; Sir Charles Gairdner Hospital
- Amanda Devine🇦🇺Edith Cowan University; The University of Western Australia; Sir Charles Gairdner Hospital
- David G. Bruce🇦🇺Edith Cowan University; The University of Western Australia; Sir Charles Gairdner Hospital
- Richard Lewis Prince🇦🇺Edith Cowan University; The University of Western Australia; Sir Charles Gairdner Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To evaluate the effects of vitamin D treatment on muscle strength and mobility in older women with vitamin D insufficiency.
Design
One-year population-based, double-blind, randomized, controlled trial.
Setting
Perth, Australia (latitude 32°S).
Participants
Three hundred two community-dwelling ambulant elderly women aged 70 to 90 with a serum 25-hydroxyvitamin D (25(OH)D) concentration less than 24 ng/mL.
Intervention
Vitamin D(2) 1,000 IU/d or identical placebo; calcium citrate (1 g calcium/d) in both groups.
Measurements
Lower limb muscle strength and mobility as assessed using the Timed Up and Go Test (TUAG).
Results
At baseline, mean ± standard deviation serum 25(OH)D was 17.7 ± 4.2 ng/mL; this increased to 24.0 ± 5.6 ng/mL in the vitamin D group after 1 year but remained the same in the placebo group. For hip extensor and adductor strength and TUAG, but not for other muscle groups, a significant interaction between treatment group and baseline values was noted. In those with baseline values in the lowest tertile, vitamin D improved muscle strength and TUAG more than calcium alone (mean (standard error): hip extensors 22.6% (9.5%); hip adductors 13.5% (6.7%), TUAG 17.5% (7.6%), P < .05). Baseline 25(OH)D levels did not influence patient response to supplementation.
Conclusion
Vitamin D therapy was observed to increase muscle function in those who were the weakest and slowest at baseline. Vitamin D should be given to people with insufficiency or deficiency to improve muscle strength and mobility.
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