Preservation of micronutrients during rapeseed oil refining: a tool to optimize the health value of edible vegetable oils? Rationale and design of the Optim'Oils randomized clinical trial
Gladine C, Meunier N, Blot A, Bruchet L, Pagès X, Gaud M, Floter E, Metin Z, Rossignol A, Cano N, Chardigny JM
Contemporary clinical trials · 7 citas
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Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-11-11 · Contemp Clin Trials · vol. 32 · número 2 · págs. 233–239
- Editorial
- Elsevier BV
- Citado
- 18 citas · más que el 62% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 13 trabajos
- Acceso
- De pago
- Áreas de investigación
- Edible Oils Quality and Analysis · Fatty Acid Research and Health · Nuts composition and effects
- Palabras clave
- rapeseed oil, oil refining, micronutrient retention, phytosterols, polyphenols, tocopherols, coenzyme Q10, coenzyme Q9, margarine, cardiovascular risk, oxidative stress, cardiovascular biomarkers, postprandial response
- MeSH
- humans, cardiovascular diseases, lipids, fatty acids, monounsaturated, plant oils, micronutrients, diet, cross-over studies, double-blind method, oxidative stress, food handling, adult, aged, middle aged, male, cholesterol, hdl, randomized controlled trials as topic, rapeseed oil
11 autores
- Cécile Gladine🇫🇷 · autor de correspondenciaUniversité Clermont Auvergne; Unité de Nutrition Humaine; Centre de Recherche en Nutrition Humaine d'Auvergne; Université de Clermont I
- Nathalie Meunier🇫🇷Centre de Recherche en Nutrition Humaine d'Auvergne
- Adeline Blot🇫🇷Centre de Recherche en Nutrition Humaine d'Auvergne
- Lucile Bruchet🇫🇷Centre de Recherche en Nutrition Humaine d'Auvergne
- X. Pagès🇫🇷Institut des Corps Gras
- Marie Gaud🇫🇷Institut des Corps Gras
- Eckhard Flöter🇳🇱Unilever Research and Development Vlaardingen
- Z. Metin🇳🇱Unilever Research and Development Vlaardingen
- Anne Rossignol‐Castera🇫🇷Institut des Corps Gras
- N. Cano🇫🇷Centre de Recherche en Nutrition Humaine d'Auvergne
- Jean‐Michel Chardigny🇫🇷Université Clermont Auvergne; Unité de Nutrition Humaine; Centre de Recherche en Nutrition Humaine d'Auvergne; Université de Clermont I
Resumen
El texto original del estudio, en el idioma en que se publicó.
Numerous micronutrients naturally abundant in oilseeds prevent the risk of cardiovascular diseases by reducing cholesterolemia and oxidative stress. These micronutrients include phytosterols and various antioxidants such as polyphenols, tocopherols and coenzyme Q10/Q9 but most of them are lost during the oilseed oil refining. The main objective of the Optim'Oil project was to modify the processes of oil refining in order to reduce the lost of micronutrients. Two clinical trials (cross-over, monocentric, randomized, double-blind and controlled) were designed to investigate the effect of an optimized rapeseed oil 1) on cardiovascular biomarkers (long-term study) and 2) on oxidative stress parameters (post-prandial study). For the long-term study, 59 volunteers ingested daily 20 g of oil and 22 g of margarine (optimized or standard) for 2 periods of 3 weeks separated by a 3-week wash-out period. Blood samples were collected at the beginning and at the end of each period. For the post-prandial study, a sub-group of 16 volunteers came fasted at the laboratory and took 300 mL of a test meal containing 60% of the optimized or standard oils. Blood samples were collected before and during 6h after the test meal intake. In comparison with the standard oil and margarine, the optimized oil and margarine exhibit as expected an increased content of phytosterol (+22%), polyphenols (× 11), tocopherols (+131%) and coenzyme Q10/Q9 (+165%). Overall, conditions of this study were relevant to investigate the effect of the optimized rapeseed oil and margarine on the cardiovascular risk and the oxidative stress.
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