Financiado en parte por Bristol-Myers Squibb Foundation, Bristol-Myers Squibb, Nutricia Research Foundation
Growth of infants fed formula rich in canola oil (low erucic acid rapeseed oil)
Rzehak P, Koletzko S, Koletzko B, Sausenthaler S, Reinhardt D, Grübl A, Bauer CP, Krämer U, Bollrath C, von Berg A, Berdel D, Wichmann HE, Heinrich J, GINI Study Group
Clinical nutrition (Edinburgh, Scotland) · 11 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Bristol-Myers Squibb Foundation
- Empresa
- Bristol-Myers Squibb
- Empresa
- Nutricia Research Foundation
Según 3 financiadores declarados.
Publicación
- Publicado
- 2010-12-04 · Clin Nutr · vol. 30 · número 3 · págs. 339–345
- Editorial
- Elsevier BV
- Citado
- 18 citas · más que el 81% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 26 trabajos
- Acceso
- De pago
- Áreas de investigación
- Infant Nutrition and Health · Fatty Acid Research and Health · Child Nutrition and Water Access
- Palabras clave
- canola oil, infant formula, infant growth, weight gain, length gain, low erucic acid rapeseed oil, formula safety, term infants, WHO Child Growth Standards
- MeSH
- humans, brassica rapa, seeds, body weight, weight gain, fatty acids, monounsaturated, erucic acids, plant oils, body height, retrospective studies, cohort studies, double-blind method, child development, infant formula, infant, infant, newborn, germany, female, male, statistics as topic, rapeseed oil
13 autores
- Peter Rzehak🇩🇪 · autor de correspondenciaHelmholtz Munich; Ludwig-Maximilians-Universität München
- Sibylle Koletzko🇩🇪Ludwig-Maximilians-Universität München
- Berthold Viktor Koletzko🇩🇪Ludwig-Maximilians-Universität München
- Stefanie Sausenthaler🇩🇪Helmholtz Munich
- Dietrich Reinhardt🇩🇪Ludwig-Maximilians-Universität München
- Armin Grübl🇩🇪Technical University of Munich
- Carl Peter Bauer🇩🇪Technical University of Munich
- Ursula Krämer🇩🇪Leibniz Institute of Environmental Medicine; Heinrich Heine University Düsseldorf
- Christina Bollrath🇩🇪Marien Hospital Wesel
- Andrea v. Berg🇩🇪Marien Hospital Wesel
- Dietrich Berdel🇩🇪Marien Hospital Wesel
- H.‐Erich Wichmann🇩🇪Helmholtz Munich; Ludwig-Maximilians-Universität München
- Joachim Heinrich🇩🇪Helmholtz Munich
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Canola oil is a variety of rapeseed oil low in erucic acid (<2%). For many years, canola oil has been widely used as an ingredient in infant formula in Europe, but not in North America due to safety concerns. A number of studies have used variable canola content of infant formulas to investigate the effects of linoleic acid: α-linolenic acid ratio on visual function of infants. However, little published data is available to compare the safety of canola versus non-canola containing infant formula. The aim of this study is to investigate whether infant formulas containing canola oil support normal growth in infants as assessed by weight and length gain.
Methods
Re-analyses of data on infant weight and length gain from a prospective randomized double-blind trial in full-term infants in the German Infant Nutritional Intervention study (GINI). This analysis compared growth in infants receiving infant formulas with or without canola oil from week 4 to month 7. Absolute weight and length, weight and length gain in gram or cm per day and standardized weight and length measurements were analyzed by analyses of variance and a longitudinal random effects model. Standardization was conducted according to the new WHO 2006 age- and sex-specific child growth standards.
Results
Absolute and standardized weight and length measures did not differ between the formula groups with or without canola oil. This was true for both, analyses within each of the three anthropometric measurement periods (4-6 weeks, 3-4 months, 6-7 months) and for the longitudinal analyses over the whole period from 4 weeks to 7 months of life. Power analyses confirmed that sample size was sufficient to detect a difference of 3 g per day between 14 and 120 days between the two formula groups.
Conclusions
Infant formula containing canola oil supports normal infant growth as assessed by weight and length gain.
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