Effect of vitamin D supplementation on testosterone levels in men
Pilz S, Frisch S, Koertke H, Kuhn J, Dreier J, Obermayer-Pietsch B, Wehr E, Zittermann A
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 181 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-12-10 · Horm Metab Res · vol. 43 · número 03 · págs. 223–225
- Editorial
- Thieme Medical Publishers (Germany)
- Citado
- 324 citas · más que el 97% de estudios similares · 6.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 0 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Hormonal and reproductive studies · Sperm and Testicular Function
- Palabras clave
- vitamin D supplementation, testosterone, 25-hydroxyvitamin D, free testosterone, male reproductive tract, vitamin D deficiency, weight loss, overweight men
- MeSH
- humans, obesity, testosterone, vitamin d, dietary supplements, adult, middle aged
8 autores
- Stefan Pilz🇦🇹Medical University of Graz
- Sabine Frisch🇩🇪Heart and Diabetes Center North Rhine-Westphalia; Ruhr University Bochum
- Heinrich Koertke🇩🇪Heart and Diabetes Center North Rhine-Westphalia; Ruhr University Bochum
- Joachim Kühn🇩🇪Heart and Diabetes Center North Rhine-Westphalia; Ruhr University Bochum
- Jens Dreier🇩🇪Heart and Diabetes Center North Rhine-Westphalia; Ruhr University Bochum
- Barbara Maria Obermayer-Pietsch🇦🇹Medical University of Graz
- Elisabeth Wehr🇦🇹Medical University of Graz
- Armin Zittermann🇩🇪Heart and Diabetes Center North Rhine-Westphalia; Ruhr University Bochum
Resumen
El texto original del estudio, en el idioma en que se publicó.
The male reproductive tract has been identified as a target tissue for vitamin D, and previous data suggest an association of 25-hydroxyvitamin D [25(OH)D] with testosterone levels in men. We therefore aimed to evaluate whether vitamin D supplementation influences testosterone levels in men. Healthy overweight men undergoing a weight reduction program who participated in a randomized controlled trial were analyzed for testosterone levels. The entire study included 200 nondiabetic subjects, of whom 165 participants (54 men) completed the trial. Participants received either 83 μg (3,332 IU) vitamin D daily for 1 year (n = 31) or placebo (n =2 3). Initial 25(OH)D concentrations were in the deficiency range (< 50 nmol/l) and testosterone values were at the lower end of the reference range (9.09-55.28 nmol/l for males aged 20-49 years) in both groups. Mean circulating 25(OH)D concentrations increased significantly by 53.5 nmol/l in the vitamin D group, but remained almost constant in the placebo group. Compared to baseline values, a significant increase in total testosterone levels (from 10.7 ± 3.9 nmol/l to 13.4 ± 4.7 nmol/l; p < 0.001), bioactive testosterone (from 5.21 ± 1.87 nmol/l to 6.25 ± 2.01 nmol/l; p = 0.001), and free testosterone levels (from 0.222 ± 0.080 nmol/l to 0.267 ± 0.087 nmol/l; p = 0.001) were observed in the vitamin D supplemented group. By contrast, there was no significant change in any testosterone measure in the placebo group. Our results suggest that vitamin D supplementation might increase testosterone levels. Further randomized controlled trials are warranted to confirm this hypothesis.
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