Financiado en parte por Burroughs Wellcome Fund, General Mills
Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals
Chacko SA, Sul J, Song Y, Li X, LeBlanc J, You Y, Butch A, Liu S
The American journal of clinical nutrition · 77 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Burroughs Wellcome Fund
- Empresa
- General Mills
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Center for Research Resources (M01‐RR000865); National Institute of Diabetes and Digestive and Kidney Diseases (K01 DK078846)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2010-12-16 · Am J Clin Nutr · vol. 93 · número 2 · págs. 463–473
- Editorial
- Elsevier BV
- Citado
- 105 citas · más que el 94% de estudios similares · 4.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Magnesium Alloys: Properties and Applications · Magnesium Oxide Properties and Applications
- Palabras clave
- magnesium supplementation, magnesium citrate, overweight, insulin, C-peptide, gene expression profiling, urine proteomics, inflammatory markers, metabolic biomarkers, PPBP
- MeSH
- humans, obesity, inflammation, magnesium, trace elements, citric acid, organometallic compounds, insulin, c-reactive protein, proteome, pilot projects, cross-over studies, double-blind method, gene expression profiling, signal transduction, gene expression regulation, dietary supplements, adult, aged, middle aged, female, male, biomarkers
8 autores
- Sara A. Chacko🇺🇸University of California, Los Angeles
- James H. Sul🇺🇸University of California, Los Angeles
- Yiqing Song🇺🇸University of California, Los Angeles
- Xin‐Min Li🇺🇸University of California, Los Angeles
- James F. LeBlanc🇺🇸University of California, Los Angeles
- Yuko You🇺🇸University of California, Los Angeles
- Anthony W. Butch🇺🇸University of California, Los Angeles
- Simin Liu🇺🇸 · autor de correspondenciaUniversity of California, Los Angeles
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Dietary magnesium intake has been favorably associated with reduced risk of metabolic outcomes in observational studies; however, few randomized trials have introduced a systems-biology approach to explore molecular mechanisms of pleiotropic metabolic actions of magnesium supplementation.
Objective
We examined the effects of oral magnesium supplementation on metabolic biomarkers and global genomic and proteomic profiling in overweight individuals.
Design
We undertook this randomized, crossover, pilot trial in 14 healthy, overweight volunteers [body mass index (in kg/m(2)) ≥25] who were randomly assigned to receive magnesium citrate (500 mg elemental Mg/d) or a placebo for 4 wk with a 1-mo washout period. Fasting blood and urine specimens were collected according to standardized protocols. Biochemical assays were conducted on blood specimens. RNA was extracted and subsequently hybridized with the Human Gene ST 1.0 array (Affymetrix, Santa Clara, CA). Urine proteomic profiling was analyzed with the CM10 ProteinChip array (Bio-Rad Laboratories, Hercules, CA).
Results
We observed that magnesium treatment significantly decreased fasting C-peptide concentrations (change: -0.4 ng/mL after magnesium treatment compared with +0.05 ng/mL after placebo treatment; P = 0.004) and appeared to decrease fasting insulin concentrations (change: -2.2 μU/mL after magnesium treatment compared with 0.0 μU/mL after placebo treatment; P = 0.25). No consistent patterns were observed across inflammatory biomarkers. Gene expression profiling revealed up-regulation of 24 genes and down-regulation of 36 genes including genes related to metabolic and inflammatory pathways such as C1q and tumor necrosis factor-related protein 9 (C1QTNF9) and pro-platelet basic protein (PPBP). Urine proteomic profiling showed significant differences in the expression amounts of several peptides and proteins after treatment.
Conclusion
Magnesium supplementation for 4 wk in overweight individuals led to distinct changes in gene expression and proteomic profiling consistent with favorable effects on several metabolic pathways. This trial was registered at clinicaltrials.gov as NCT00737815.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.