Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial
Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, Mittendorfer B
The American journal of clinical nutrition · 448 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
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Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Ellison Medical Foundation
- Organización sin fines de lucro
- Longer Life Foundation
- Gobierno
- Research Councils UK
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- European Commission
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- National Institutes of Health
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- Directorate for Biological Sciences
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- Biotechnology and Biological Sciences Research Council
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- National Institute of Diabetes and Digestive and Kidney Diseases
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- National Institute of Arthritis and Musculoskeletal and Skin Diseases
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- National Center for Research Resources
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- National Center for Advancing Translational Sciences
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- NIAMS NIH HHS
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- NCRR NIH HHS
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- NCATS NIH HHS
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- NIDDK NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK056341); National Center for Advancing Translational Sciences (UL1-TR-000448); Biotechnology and Biological Sciences Research Council (BB/C516779/1); National Institute of Diabetes and Digestive and Kidney Diseases (DK56341); National Center for Research Resources (UL1RR-024992); National Center for Research Resources (RR-024992); National Center for Research Resources (RR 00954); National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR49869); National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR049869); Biotechnology and Biological Sciences Research Council (BB/XX510697/1); National Institutes of Health (DK56341); National Institutes of Health (AR 49869); National Institutes of Health (UL1 RR024992); National Institutes of Health (RR-00954); National Institutes of Health (RR024992)
Según 15 financiadores declarados.
Publicación
- Publicado
- 2010-12-15 · Am J Clin Nutr · vol. 93 · número 2 · págs. 402–412
- Editorial
- Elsevier BV
- Citado
- 665 citas · más que el 99% de estudios similares · 10.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Muscle metabolism and nutrition · Fatty Acid Research and Health · Nutrition and Health in Aging
- Palabras clave
- omega-3 fatty acids, muscle protein synthesis, sarcopenia, older adults, mTOR signaling, p70S6K, protein anabolism, dietary supplementation, corn oil
- MeSH
- humans, hyperinsulinism, insulin, dietary fats, corn oil, fatty acids, omega-3, amino acids, muscle proteins, signal transduction, protein biosynthesis, phosphorylation, dietary supplements, aged, female, male, sarcopenia
7 autores
- Gordon Ian Smith🇺🇸Washington University in St. Louis
- Philip James Atherton🇬🇧🇺🇸University of Nottingham; Washington University in St. Louis
- Dominic N. Reeds🇬🇧🇺🇸University of Nottingham; Washington University in St. Louis
- B. Selma Mohammed🇬🇧🇺🇸University of Nottingham; Washington University in St. Louis
- Debbie Rankin🇬🇧🇺🇸University of Nottingham; Washington University in St. Louis
- Michael J. Rennie🇬🇧🇺🇸University of Nottingham; Washington University in St. Louis
- Bettina Mittendorfer🇬🇧🇺🇸University of Nottingham; Washington University in St. Louis
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Loss of muscle mass with aging is a major public health concern. Omega-3 (n-3) fatty acids stimulate protein anabolism in animals and might therefore be useful for the treatment of sarcopenia. However, the effect of omega-3 fatty acids on human protein metabolism is unknown.
Objective
The objective of this study was to evaluate the effect of omega-3 fatty acid supplementation on the rate of muscle protein synthesis in older adults.
Design
Sixteen healthy, older adults were randomly assigned to receive either omega-3 fatty acids or corn oil for 8 wk. The rate of muscle protein synthesis and the phosphorylation of key elements of the anabolic signaling pathway were evaluated before and after supplementation during basal, postabsorptive conditions and during a hyperaminoacidemic-hyperinsulinemic clamp.
Results
Corn oil supplementation had no effect on the muscle protein synthesis rate and the extent of anabolic signaling element phosphorylation in muscle. Omega-3 fatty acid supplementation had no effect on the basal rate of muscle protein synthesis (mean ± SEM: 0.051 ± 0.005%/h compared with 0.053 ± 0.008%/h before and after supplementation, respectively; P = 0.80) but augmented the hyperaminoacidemia-hyperinsulinemia-induced increase in the rate of muscle protein synthesis (from 0.009 ± 0.005%/h above basal values to 0.031 ± 0.003%/h above basal values; P < 0.01), which was accompanied by greater increases in muscle mTOR(Ser2448) (P = 0.08) and p70s6k(Thr389) (P < 0.01) phosphorylation.
Conclusion
Omega-3 fatty acids stimulate muscle protein synthesis in older adults and may be useful for the prevention and treatment of sarcopenia. This trial was registered at clinical trials.gov as NCT00794079.
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