Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia
Skulas-Ray AC, Kris-Etherton PM, Harris WS, Vanden Heuvel JP, Wagner PR, West SG
The American journal of clinical nutrition · 196 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Center for Research Resources (M01 RR10732); National Center for Research Resources (M01-RR-010732)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2010-12-15 · Am J Clin Nutr · vol. 93 · número 2 · págs. 243–252
- Editorial
- Elsevier BV
- Citado
- 279 citas · más que el 100% de estudios similares · 22.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 69 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Aquaculture Nutrition and Growth · Nutritional Studies and Diet
- Palabras clave
- omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, hypertriglyceridemia, dose-response relationship, serum triglycerides, endothelial function, inflammation, inflammatory cytokines, C-reactive protein, flow-mediated dilation, postmenopausal women, healthy adults
- MeSH
- endothelium, vascular, humans, hypertriglyceridemia, inflammation, dietary fats, fatty acids, omega-3, triglycerides, inflammation mediators, cross-over studies, double-blind method, postmenopause, dose-response relationship, drug, reference values, adult, aged, middle aged, female, male, young adult, biomarkers
6 autores
- Ann C. Skulas‐Ray🇺🇸 · autor de correspondenciaPennsylvania State University
- Penny M. Kris‐Etherton🇺🇸Pennsylvania State University
- William Stephen Harris🇺🇸University of South Dakota
- John P. Vanden Heuvel
- Paul R. Wagner
- Sheila G. West🇺🇸Pennsylvania State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been shown to reduce cardiovascular mortality at a dose of ≈1 g/d. Studies using higher doses have shown evidence of reduced inflammation and improved endothelial function. Few studies have compared these doses.
Objective
The objective of this study was to compare the effects of a nutritional dose of EPA+DHA (0.85 g/d) with those of a pharmaceutical dose (3.4 g/d) on serum triglycerides, inflammatory markers, and endothelial function in healthy subjects with moderately elevated triglycerides.
Design
This was a placebo-controlled, double-blind, randomized, 3-period crossover trial (8 wk of treatment, 6 wk of washout) that compared the effects of 0.85 and 3.4 g EPA+DHA/d in 23 men and 3 postmenopausal women with moderate hypertriglyceridemia (150-500 mg/dL).
Results
The higher dose of EPA+DHA lowered triglycerides by 27% compared with placebo (mean ± SEM: 173 ± 17.5 compared with 237 ± 17.5 mg/dL; P = 0.002), whereas no effect of the lower dose was observed on lipids. No effects on cholesterol (total, LDL, and HDL), endothelial function [as assessed by flow-mediated dilation, peripheral arterial tonometry/EndoPAT (Itamar Medical Ltd, Caesarea, Israel), or Doppler measures of hyperemia], inflammatory markers (interleukin-1β, interleukin-6, tumor necrosis factor-α, and high-sensitivity C-reactive protein), or the expression of inflammatory cytokine genes in isolated lymphocytes were observed.
Conclusion
The higher dose (3.4 g/d) of EPA+DHA significantly lowered triglycerides, but neither dose improved endothelial function or inflammatory status over 8 wk in healthy adults with moderate hypertriglyceridemia. The trial was registered at clinicaltrials.gov as NCT00504309.
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