Relationship between vitamin D, parathyroid hormone, and bone health
Sai AJ, Walters RW, Fang X, Gallagher JC
The Journal of clinical endocrinology and metabolism · 194 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institute on Aging (AG28168); National Institute on Aging (R01AG10358); National Institute on Aging (UO1-AG10373); National Institute on Aging (R01 AG028168)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2010-12-16 · J Clin Endocrinol Metab · vol. 96 · número 3 · págs. E436–E446
- Editorial
- Oxford University Press
- Citado
- 276 citas · más que el 99% de estudios similares · 14.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 87 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Parathyroid Disorders and Treatments
- Palabras clave
- vitamin D insufficiency, 25-hydroxyvitamin D, parathyroid hormone, bone health, osteocalcin, N-telopeptide, calcium absorption, older women, bone turnover markers
- MeSH
- bone and bones, humans, vitamin d deficiency, calcium, hydroxycholecalciferols, parathyroid hormone, vitamin d, osteocalcin, linear models, cross-sectional studies, nutritional status, aging, sex characteristics, geography, reference standards, aged, health, united states, female, male, biomarkers
4 autores
- Adarsh J. Sai🇺🇸 · autor de correspondenciaCreighton University; CHI Health Creighton University Medical Center - Bergan Mercy
- Ryan William Walters🇺🇸Creighton University; CHI Health Creighton University Medical Center - Bergan Mercy
- Xiang Fang🇺🇸Creighton University
- John Christopher Gallagher🇺🇸Creighton University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
There is a controversy regarding the definition of vitamin D insufficiency as it relates to bone health.
Objective
The objective of the study was to examine the evidence for a threshold value of serum 25-hydroxyvitamin D (25OHD) that defines vitamin D insufficiency as it relates to bone health.
Design and participants
This was a cross-sectional analysis of baseline data in 488 elderly Caucasian women, mean age 71 yr, combined with a literature review of 70 studies on the relationship of serum PTH to serum 25OHD.
Setting
The study was conducted in independent-living women in the midwest United States.
Main outcome measure
The relationship between serum 25OHD, serum PTH, and serum osteocalcin and 24-h urine N-telopeptides was evaluated.
Results
Serum PTH was inversely correlated with serum 25OHD (r = -0.256, P < 0.0005), but no threshold as defined by suppression of serum PTH was found within the serum 25OHD range 6-60 ng/ml (15-150 nmol/liter). However, in contrast, there was a threshold for bone markers, serum osteocalcin and urine N-telopeptides, that increased only below a serum 25OHD of approximately 18 ng/ml (45 nmol/liter). Calcium absorption was not correlated with serum PTH and serum 25OHD, and no threshold was found. A literature review of 70 studies generally showed a threshold for serum PTH with increasing serum 25OHD, but there was no consistency in the threshold level of serum 25OHD that varied from 10 to 50 ng/ml (25-125 nmol/liter).
Conclusions
Vitamin D insufficiency should be defined as serum 25OHD less than 20 ng/ml (50 nmol/liter) as it relates to bone.
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