Associations of circulating and dietary vitamin D with prostate cancer risk: a systematic review and dose-response meta-analysis
Gilbert R, Martin RM, Beynon R, Harris R, Savovic J, Zuccolo L, Bekkering GE, Fraser WD, Sterne JA, Metcalfe C
Cancer causes & control : CCC · 108 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Cancer Research UK
- Gobierno
- Medical Research Council
- Subvenciones
- Cancer Research UK (C31211/A10095)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2011-01-03 · Cancer Causes Control · vol. 22 · número 3 · págs. 319–340
- Editorial
- Springer Science+Business Media
- Citado
- 144 citas · más que el 89% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 67 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Prostate Cancer Treatment and Research
- Palabras clave
- vitamin D, prostate cancer, vitamin D intake, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, circulating vitamin D, aggressive prostate cancer, cancer risk, dose-response relationship
- MeSH
- humans, prostatic neoplasms, vitamins, vitamin d, diet, odds ratio, risk, case-control studies, prospective studies, male
10 autores
- Rebecca Gilbert🇬🇧 · autor de correspondenciaUniversity of Bristol
- Richard Michael Martin🇬🇧University of Bristol
- Rebecca Beynon🇬🇧University of Bristol
- Ross Harris🇬🇧Health Protection Agency
- Jelena Savović🇬🇧University of Bristol
- Luisa Zuccolo🇬🇧University of Bristol
- Geertruida Elsiena Bekkering🇧🇪Bekaert (Belgium); KU Leuven
- William Duncan Fraser🇬🇧University of Liverpool
- Jonathan A C Sterne🇬🇧University of Bristol
- Chris D. Metcalfe🇬🇧University of Bristol
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
We systematically reviewed and meta-analyzed literature examining associations of vitamin D (dietary intake, circulating 25-hydroxy-vitamin-D (25(OH)D), and 1,25-dihydroxy-vitamin-D (1,25(OH)(2)D) concentrations) with prostate cancer.
Methods
We searched over 24,000 papers from seven electronic databases (to October 2010) for exposures related to vitamin D. We conducted dose-response random-effects meta-analyses pooling the log odds ratio (OR) and 95% confidence intervals (CI) per change in natural units of each exposure. The I(2) statistic quantified between-study variation due to heterogeneity.
Results
Twenty-five papers were included. In prospective studies, the OR per 1,000 IU increase in dietary intake was 1.14 (6 studies; CI: 0.99, 1.31; I (2) = 0%) for total prostate cancer and 0.93 (3 studies; 0.63, 1.39; I (2) = 25%) for aggressive prostate cancer. Five case-control studies examined dietary intake, but there was a high degree of inconsistency between studies (I (2) = 49%). The OR per 10 ng/mL increase in 25(OH)D was 1.04 (14 studies; 0.99, 1.10; I (2) = 0%) for total prostate cancer and 0.98 (6 studies; 0.84, 1.15; I (2) = 32%) for aggressive prostate cancer. The OR per 10 pg/mL increase in 1,25(OH)(2)D was 1.00 (7 studies; 0.87, 1.14; I (2) = 41%) for total prostate cancer and 0.86 (2 studies; 0.72, 1.02; I (2) = 0%) for aggressive prostate cancer.
Conclusion
Published literature provides little evidence to support a major role of vitamin D in preventing prostate cancer or its progression.
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