A randomized clinical trial on the effect of low-level laser therapy on chronic diabetic foot wound healing: a preliminary report
Kaviani A, Djavid GE, Ataie-Fashtami L, Fateh M, Ghodsi M, Salami M, Zand N, Kashef N, Larijani B
Photomedicine and laser surgery · 89 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-01-09 · Photomed Laser Surg · vol. 29 · número 2 · págs. 109–114
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 134 citas · más que el 92% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Wound Healing and Treatments · Diabetic Foot Ulcer Assessment and Management
- Palabras clave
- low-level laser therapy, diabetic foot ulcer, chronic wound healing, diabetes mellitus, ulcer size reduction, microcirculation
- MeSH
- humans, diabetic foot, chronic disease, double-blind method, wound healing, aged, middle aged, female, male, low-level light therapy
9 autores
- Ahmad Kaviani🇮🇷Imam Khomeini Hospital; Tehran University of Medical Sciences
- Gholamreza Esmaeeli Djavid🇮🇷 · autor de correspondenciaAcademic Center for Education, Culture and Research
- Leila Ataie‐Fashtami🇮🇷Academic Center for Education, Culture and Research
- Mohsen Fateh🇮🇷Academic Center for Education, Culture and Research
- Maryam Ghodsi🇮🇷Shariati Hospital; Endocrine and Metabolism Research Center
- ملیحه سلامی🇮🇷Academic Center for Education, Culture and Research
- Nasrin Zand🇮🇷Academic Center for Education, Culture and Research
- Nasim Kashef🇮🇷University of Tehran
- Bagher A. Larijani🇮🇷Shariati Hospital; Endocrine and Metabolism Research Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objectives
Low-level laser therapy (LLLT) has been shown to promote chronic wound healing in conditions of reduced microcirculation. In this preliminary study, we report the results of using LLLT to heal foot ulcers in patients with diabetes mellitus.
Materials and methods
Twenty-three patients with a diabetic foot wound for at least 3 months were included in this double-blind randomized clinical trial. Patients were randomized to receive placebo treatment (n = 10) or LLLT (n = 13) (685 nm, energy density 10 J/cm(2)) in addition to conventional therapy. Patients were followed for 20 weeks. Ulcer size reduction and the number of patients with complete healing were compared between the LLLT and placebo groups.
Results
There were no significant differences in baseline characteristics of patients and foot ulcers receiving LLLT and placebo treatment. At week 4, the size of ulcers decreased significantly in the LLLT group (p = 0.04). After 20 weeks, in the LLLT group, eight patients had complete healing and in the placebo group only three patients experienced complete wound healing. The mean time of complete healing in LLLT patients (11 weeks) was less than that in placebo patients (14 weeks) though the difference was not statistically significant.
Conclusions
The study provides evidence that LLLT can accelerate the healing process of chronic diabetic foot ulcers, and it can be presumed that LLLT may shorten the time period needed to achieve complete healing.
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