Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial
Nobili V, Bedogni G, Alisi A, Pietrobattista A, Risé P, Galli C, Agostoni C
Archives of disease in childhood · 198 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-01-12 · Arch Dis Child · vol. 96 · número 4 · págs. 350–353
- Editorial
- BMJ
- Citado
- 256 citas · más que el 100% de estudios similares · 16.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- De pago
- Áreas de investigación
- Liver Disease Diagnosis and Treatment · Fatty Acid Research and Health · Aquaculture Nutrition and Growth
- Palabras clave
- docosahexaenoic acid, omega-3 supplementation, non-alcoholic fatty liver disease, pediatric NAFLD, hepatic steatosis, liver fat, insulin sensitivity, triglycerides, alanine aminotransferase, body mass index
- MeSH
- humans, fatty liver, insulin resistance, alanine transaminase, docosahexaenoic acids, triglycerides, ultrasonography, treatment outcome, double-blind method, dose-response relationship, drug, dietary supplements, adolescent, child, female, male, non-alcoholic fatty liver disease
7 autores
- Valério Nobili🇮🇹 · autor de correspondenciaBambino Gesù Children's Hospital; Istituti di Ricovero e Cura a Carattere Scientifico
- Giorgio Bedogni🇮🇹University of Milan; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Anna Alisi🇮🇹Bambino Gesù Children's Hospital; Istituti di Ricovero e Cura a Carattere Scientifico
- Andrea Pietrobattista🇮🇹Bambino Gesù Children's Hospital; Istituti di Ricovero e Cura a Carattere Scientifico
- Patrizia Risé🇮🇹University of Milan
- Claudio Galli🇮🇹University of Milan
- Carlo Virginio Agostoni🇮🇹University of Milan; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To investigate whether dietary supplementation with docosahexaenoic acid (DHA) decreases liver fat content in children with non-alcoholic fatty liver disease (NAFLD).
Design, setting and patients
We performed a randomised controlled trial of DHA supplementation (250 and 500 mg/day) versus placebo in 60 children with biopsy-proven NAFLD (20 children per group).
Main outcome measures
The main outcome was the change in liver fat content as detected by ultrasonography after 6 months of treatment. Secondary outcomes were the changes in insulin sensitivity index, alanine transaminase, triglycerides and body mass index after 6 months of treatment.
Results
Blood DHA increased in children supplemented with DHA (0.65%, 95% CI 0.30% to 1.10% for the DHA 250 mg group and 1.15%, 0.87% to 1.43% for the DHA 500 mg group). The odds of more severe versus less severe liver steatosis after treatment was lower in children treated with DHA 250 mg/day (OR = 0.01, 0.002 to 0.11, p <0.001) and DHA 500 mg/day (OR = 0.04, 0.002 to 0.46, p = 0.01) as compared to placebo but there was no difference between the DHA groups (p = 0.4). Insulin sensitivity index increased and triglycerides decreased to a similar degree in both DHA groups as compared to placebo but there was no effect on alanine transaminase and body mass index.
Conclusion
DHA supplementation improves liver steatosis and insulin sensitivity in children with NAFLD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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