The efficacy of host response modulation therapy (omega-3 plus low-dose aspirin) as an adjunctive treatment of chronic periodontitis (clinical and biochemical study)
Elkhouli AM
Journal of periodontal research · 81 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-01-25 · J Periodontal Res · vol. 46 · número 2 · págs. 261–268
- Editorial
- Wiley
- Citado
- 104 citas · más que el 97% de estudios similares · 6.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 61 trabajos
- Acceso
- De pago
- Áreas de investigación
- Periodontal Regeneration and Treatments · Oral microbiology and periodontitis research · Dental Implant Techniques and Outcomes
- Palabras clave
- chronic periodontitis, omega-3 polyunsaturated fatty acids, low-dose aspirin, host response modulation, furcation defects, adjunctive periodontal therapy, regenerative periodontal therapy, gingival crevicular fluid, IL-1β, IL-10, probing depth, clinical attachment level, gingivitis
- MeSH
- gingival crevicular fluid, humans, gingival hemorrhage, furcation defects, periodontal attachment loss, periodontal pocket, aspirin, fatty acids, omega-3, anti-inflammatory agents, non-steroidal, interleukin-10, placebos, combined modality therapy, bone transplantation, guided tissue regeneration, periodontal, administration, oral, dental plaque index, periodontal index, follow-up studies, double-blind method, adult, middle aged, female, male, interleukin-1beta, chronic periodontitis, immunomodulation
1 autor
- Amr M. El-Khouli🇪🇬 · autor de correspondenciaOctober 6 University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objective
Regeneration of lost periodontal tissues is considered to be one of the most challenging aspects of periodontal therapy. Our current understanding of the role of the host immuno-inflammatory response in periodontal diseases forms the basis of new therapeutic approaches. The aim of this study was to evaluate the efficacy of systemic administration of omega-3 polyunsaturated fatty acids plus low-dose aspirin as an adjunctive treatment to regenerative therapy of furcation defects.
Material and methods
Forty patients displaying at least a single grade II furcation defect were enrolled in the study. They were randomly allocated into two groups: an experimental group receiving decalcified freeze-dried bone allograft (DFDBA) + omega-3 polyunsaturated fatty acids combined with low-dose aspirin; and a control group receiving DFDBA + placebo. Clinical parameters were monitored at baseline, and at 3 and 6 mo following therapy, and included plaque index, gingival index, gingival bleeding index, probing pocket depth and clinical attachment level. The biochemical markers assessed in gingival crevicular fluid samples were interleukin-1β and interleukin-10.
Results
The experimental intervention resulted in a greater mean probing pocket depth reduction (P < 0.001) and gain in clinical attachment (P < 0.05) compared with the control at 6 mo. Furthermore, the experimental protocol was able to achieve a significant modulatory effect on the levels of interleukin-1β and interleukin-10 compared with control therapy.
Conclusion
The findings suggest that the combination therapy demonstrated successful reduction of gingival inflammation, reduction of pocket depth and attachment level gain, accompanied by a trend for modulation of the cytokines profile in gingival crevicular fluid.
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