Laser photobiomodulation of gene expression and release of growth factors and cytokines from cells in culture: a review of human and animal studies
Peplow PV, Chung TY, Ryan B, Baxter GD
Photomedicine and laser surgery · 90 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-02-10 · Photomed Laser Surg · vol. 29 · número 5 · págs. 285–304
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 129 citas · más que el 97% de estudios similares · 6.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Biofield Effects and Biophysics · Photodynamic Therapy Research Studies
- Palabras clave
- laser photobiomodulation, low-level laser therapy, gene expression, growth factors, cytokines, laser irradiation, wavelength dependence, radiant exposure, inflammation, cell proliferation, cell culture
- MeSH
- cells, cultured, animals, humans, intercellular signaling peptides and proteins, cytokines, lasers, gene expression, laser therapy
4 autores
- Philip V. Peplow🇳🇿 · autor de correspondenciaUniversity of Otago
- Tzu‐Yun Chung🇳🇿University of Otago
- Brigid Ryan🇳🇿University of Otago
- David G. Baxter🇳🇿University of Otago
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aim
The aim of this paper was to review experimental studies of laser irradiation of human and animal cells in culture to assess the photobiomodulatory effects of such irradiation on gene expression and release of growth factors and CYTOKINES.
Background
Previous studies have reported that the release of certain growth factors and cytokines by various types of cells can be modulated by laser irradiation. A review of recent studies may provide further insight into the clinical effects brought about by laser irradiation of cells and tissues, including changes in inflammation and cellular proliferation.
Methods
A systematic review was completed of original research papers investigating the effects of laser phototherapy on gene expression and release of these mediators from human and animal cells in culture (January 2002 to September 2009). Relevant papers were retrieved primarily from PubMed and Medline databases. The search terms were "growth factors", "cytokines", "laser therapy", "laser irradiation", "laser phototherapy," and "phototherapy".
Results
A total of 17 relevant papers were included in the review, comprising studies on a variety of cell types. Considerable variation occurred in research design, methodology, and irradiation parameters employed, limiting comparison of research findings between studies. Results demonstrated that laser irradiation at green, red, or infrared wavelengths at a range of dosage parameters can cause significant changes in the cellular gene expression and release of these mediators, and that such effects depend upon wavelength and radiant exposure.
Conclusion
Findings from the reviewed studies clearly demonstrate the ability of laser irradiation to modulate gene expression and the release of growth factors and cytokines from cells in culture. Further work is indicated at the clinical level to elucidate the putative clinical relevance of these cellular-level effects.
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