Beneficial effect of creatine supplementation in knee osteoarthritis
Neves M, Gualano B, Roschel H, Fuller R, Benatti FB, Pinto AL, Lima FR, Pereira RM, Lancha AH, Bonfá E
Medicine and science in sports and exercise · 52 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-02-10 · Med Sci Sports Exerc · vol. 43 · número 8 · págs. 1538–1543
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 76 citas · más que el 93% de estudios similares · 3.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Osteoarthritis Treatment and Mechanisms · Muscle metabolism and nutrition · Nutrition and Health in Aging
- Palabras clave
- creatine supplementation, knee osteoarthritis, postmenopausal women, resistance training, physical function, quality of life, joint pain, joint stiffness, muscle strength
- MeSH
- muscle, skeletal, humans, osteoarthritis, knee, pain, creatine, treatment outcome, exercise therapy, double-blind method, postmenopause, quality of life, dietary supplements, middle aged, female, muscle strength, resistance training
10 autores
- Manoel Neves🇧🇷Universidade de São Paulo
- Bruno Gualano🇧🇷Universidade de São Paulo
- Hamilton Roschel🇧🇷Universidade de São Paulo
- Ricardo Fuller🇧🇷Universidade de São Paulo
- Fabiana Braga Benatti🇧🇷Universidade de São Paulo
- Ana Lúcia de Sá Pinto🇧🇷Universidade de São Paulo
- Fernanda Rodrigues Lima🇧🇷Universidade de São Paulo
- Rosa Maria Rodrigues Pereira🇧🇷Universidade de São Paulo
- Antônio Herbert Lancha🇧🇷Universidade de São Paulo
- Eloísa Bonfá🇧🇷Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
The aim of this study was to investigate the efficacy of creatine (CR) supplementation combined with strengthening exercises in knee osteoarthritis (OA).
Methods
A randomized, double-blind, placebo-controlled trial was performed. Postmenopausal women with knee OA were allocated to receive either CR (20 g·d(-1) for 1 wk and 5 g·d(-1) thereafter) or placebo (PL) and were enrolled in a lower limb resistance training program. They were assessed at baseline (PRE) and after 12 wk (POST). The primary outcome was the physical function as measured by the timed-stands test. Secondary outcomes included lean mass, quality of life, pain, stiffness, and muscle strength.
Results
Physical function was significantly improved only in the CR group (P = 0.006). In addition, a significant between-group difference was observed (CR: PRE = 15.7 ± 1.4, POST = 18.1 ± 1.8; PL: PRE = 15.0 ± 1.8, POST = 15.2 ± 1.2; P = 0.004). The CR group also presented improvements in physical function and stiffness subscales as evaluated by the Western Ontario and McMaster Universities Osteoarthritis Index (P = 0.005 and P = 0.024, respectively), whereas the PL group did not show any significant changes in these parameters (P > 0.05). In addition, only the CR group presented a significant improvement in lower limb lean mass (P = 0.04) as well as in quality of life (P = 0.01). Both CR and PL groups demonstrated significant reductions in pain (P < 0.05). Similarly, a main effect for time revealed an increase in leg-press one-repetition maximum (P = 0.005) with no significant differences between groups (P = 0.81).
Conclusions
CR supplementation improves physical function, lower limb lean mass, and quality of life in postmenopausal women with knee OA undergoing strengthening exercises.
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