Glucose and caffeine effects on sustained attention: an exploratory fMRI study
Serra-Grabulosa JM, Adan A, Falcón C, Bargalló N
Human psychopharmacology · 31 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2010-10-26 · Hum Psychopharmacol · vol. 25 · número 7-8 · págs. 543–552
- Editorial
- Wiley
- Citado
- 52 citas · más que el 89% de estudios similares · 2.9× el promedio de su campo
- Referencias
- 56 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Sleep and Work-Related Fatigue · Mind wandering and attention
- Palabras clave
- caffeine, glucose, sustained attention, continuous performance test, parietal cortex, prefrontal cortex, working memory, cognitive performance, neural basis of attention
- MeSH
- brain, prefrontal cortex, humans, caffeine, glucose, blood glucose, central nervous system stimulants, sweetening agents, magnetic resonance imaging, memory, attention, adolescent, adult, female, functional laterality, young adult
4 autores
- Josep Maria Serra-Grabulosa🇪🇸 · autor de correspondenciaConsorci Institut D'Investigacions Biomediques August Pi I Sunyer; Universitat de Barcelona
- Ana Adán🇪🇸Universitat de Barcelona
- Carles Falcón🇪🇸Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Núria Bargalló🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Caffeine and glucose can have beneficial effects on cognitive performance. However, neural basis of these effects remain unknown. Our objective was to evaluate the effects of caffeine and glucose on sustained attention, using functional magnetic resonance imaging (fMRI).
Methods
Forty young right-handed, healthy, low caffeine-consuming subjects participated in the study. In a double-blind, randomised design, subjects received one of the following beverages: vehicle (water, 150 ml); vehicle plus 75 g of glucose; vehicle plus 75 mg of caffeine; vehicle plus 75 g of glucose and 75 mg of caffeine. Participants underwent two scanning fMRI sessions (before and 30 min after of the administration of the beverage). A continuous performance test was used to assess sustained attention.
Results
Participants who received combined caffeine and glucose had similar performance to the others but had a decrease in activation in the bilateral parietal and left prefrontal cortex.
Conclusions
Since these areas have been related to the sustained attention and working memory processes, results would suggest that combined caffeine and glucose could increase the efficiency of the attentional system. However, more studies using larger samples and different levels of caffeine and glucose are necessary to better understand the combined effects of both substances.
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