Impact of acute caffeine ingestion on endothelial function in subjects with and without coronary artery disease
Shechter M, Shalmon G, Scheinowitz M, Koren-Morag N, Feinberg MS, Harats D, Sela BA, Sharabi Y, Chouraqui P
The American journal of cardiology · 50 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-02-24 · Am J Cardiol · vol. 107 · número 9 · págs. 1255–1261
- Editorial
- Elsevier BV
- Citado
- 74 citas · más que el 92% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Cardiovascular Health and Disease Prevention · Nitric Oxide and Endothelin Effects
- Palabras clave
- acute caffeine ingestion, endothelial function, coronary artery disease, flow-mediated dilation, nitroglycerin-mediated dilation, brachial artery, C-reactive protein, inflammation, coffee, cardiovascular risk factors
- MeSH
- brachial artery, endothelium, vascular, humans, caffeine, phosphodiesterase inhibitors, case-control studies, double-blind method, regional blood flow, middle aged, female, male, coronary artery disease, biomarkers
9 autores
- Michael Shechter🇮🇱 · autor de correspondenciaTel Aviv University; Sheba Medical Center
- Guy Shalmon🇮🇱Tel Aviv University; Sheba Medical Center
- Mickey Scheinowitz🇮🇱Tel Aviv University; Sheba Medical Center
- Nira Koren‐Morag🇮🇱Tel Aviv University
- Micha S. Feinberg🇮🇱Tel Aviv University; Sheba Medical Center
- Dror Harats🇮🇱Tel Aviv University; Sheba Medical Center
- Ben Ami Sela🇮🇱Tel Aviv University; Sheba Medical Center
- Yehonatan Sharabi🇮🇱Tel Aviv University; Sheba Medical Center
- Pierre Chouraqui🇮🇱Tel Aviv University; Sheba Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Although coffee is a widely used, pharmacologically active beverage, its impact on the cardiovascular system is controversial. To explore the effect of acute caffeine ingestion on brachial artery flow-mediated dilation (FMD) in subjects without coronary artery disease (CAD; controls) and patients with CAD, we prospectively assessed brachial artery FMD in 40 controls and 40 age- and gender-matched patients with documented stable CAD on 2 separate mornings 1 week to 2 weeks apart. After overnight fasting, discontinuation of all medications for ≥12 hours, and absence of caffeine for >48 hours, participants received capsules with caffeine 200 mg or placebo. One hour after drug ingestion, participants underwent brachial artery FMD and nitroglycerin-mediated dilation (NTG) using high-resolution ultrasound. As expected, patients with CAD were more often diabetic, hypertensive, obese, dyslipidemic, and smoked more than controls (p <0.01 for all comparisons). Aspirin, Clopidogrel, angiotensin-converting enzyme inhibitors, β blockers, and statins were significantly more common in patients with CAD than in controls (p <0.01 for all comparisons). At baseline, FMD, but not NTG, was significantly lower in patients with CAD compared to controls. Acute caffeine ingestion significantly increased FMD (patients with CAD 5.6 ± 5.0% vs 14.6 ± 5.0%, controls 8.4 ± 2.9% vs 18.6 ± 6.8%, p <0.001 for all comparisons) but not NTG (patients with CAD 13.0 ± 5.2% vs 13.8 ± 6.1%, controls 12.9 ± 3.9% vs 13.9 ± 5.8%, p = NS for all comparisons) and significantly decreased high-sensitivity C-reactive protein (patients with CAD 2.6 ± 1.4 vs 1.4 ± 1.2 mg/L, controls 3.4 ± 3.0 vs 1.2 ± 1.0 mg/L, p <0.001 for all comparisons) in the 2 groups compared to placebo. In conclusion, acute caffeine ingestion significantly improved endothelial function assessed by brachial artery FMD in subjects with and without CAD and was associated with lower plasma markers of inflammation.
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