Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. A population-based intervention trial from the Tromsø study
Bønaa KH, Bjerve KS, Straume B, Gram IT, Thelle D
The New England journal of medicine · 276 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1990-03-22 · N Engl J Med · vol. 322 · número 12 · págs. 795–801
- Editorial
- Massachusetts Medical Society
- Citado
- 413 citas · más que el 100% de estudios similares · 35.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Blood Pressure and Hypertension Studies · Eicosanoids and Hypertension Pharmacology
- Palabras clave
- eicosapentaenoic acid, docosahexaenoic acid, fish oil, essential hypertension, blood pressure reduction, polyunsaturated fatty acids, dietary supplementation, corn oil, fish consumption
- MeSH
- humans, hypertension, corn oil, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, phospholipids, double-blind method, random allocation, blood pressure, food, fortified, adult, middle aged, female, male
5 autores
- Kaare Harald Bønaa🇳🇴UiT The Arctic University of Norway
- Kristian S. Bjerve🇳🇴UiT The Arctic University of Norway
- Bjørn Straume🇳🇴UiT The Arctic University of Norway
- Inger Torhild Gram🇳🇴UiT The Arctic University of Norway
- Dag Steinar Thelle🇳🇴UiT The Arctic University of Norway
Resumen
El texto original del estudio, en el idioma en que se publicó.
Studies of whether polyunsaturated fatty acids in fish oil--in particular, eicosapentaenoic and docosahexaenoic acids--lower blood pressure have varied in design and results. We conducted a population-based, randomized, 10-week dietary-supplementation trial in which the effects of 6 g per day of 85 percent eicosapentaenoic and docosahexaenoic acids were compared with those of 6 g per day of corn oil in 156 men and women with previously untreated stable, mild essential hypertension. The mean systolic blood pressure fell by 4.6 mm Hg (P = 0.002), and diastolic pressure by 3.0 mm Hg (P = 0.0002) in the group receiving fish oil; there was no significant change in the group receiving corn oil. The differences between the groups remained significant for both systolic (6.4 mm Hg; P = 0.0025) and diastolic (2.8 mm Hg; P = 0.029) pressure after control for anthropometric, lifestyle, and dietary variables. The decreases in blood pressure were larger as concentrations of plasma phospholipid n-3 fatty acids increased (P = 0.027). Dietary supplementation with fish oil did not change mean blood pressure in the subjects who ate fish three or more times a week as part of their usual diet, or in those who had a base-line concentration of plasma phospholipid n-3 fatty acids above 175.1 mg per liter. We conclude that eicosapentaenoic and docosahexaenoic acids reduce blood pressure in essential hypertension, depending on increases in plasma phospholipid n-3 fatty acids.
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