Financiado en parte por Fundação Bial
Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo
Bjørkedal E, Flaten MA
Psychopharmacology · 41 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Universitetet i Tromsø
- Empresa
- Fundação Bial
- Gobierno
- Norges Forskningsråd
Según 3 financiadores declarados.
Publicación
- Publicado
- 2011-03-08 · Psychopharmacology (Berl) · vol. 215 · número 3 · págs. 537–548
- Editorial
- Springer Science+Business Media
- Citado
- 54 citas · más que el 88% de estudios similares · 2.6× el promedio de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Pain Management and Placebo Effect · Pain Mechanisms and Treatments · Dental Anxiety and Anesthesia Techniques
- Palabras clave
- placebo analgesia, caffeine, active placebo, expectancy, adverse drug reactions, placebo response, pain perception, laser-evoked potentials, drug information
- MeSH
- humans, pain, caffeine, analgesics, central nervous system stimulants, pain measurement, double-blind method, lasers, stress, psychological, arousal, placebo effect, evoked potentials, adolescent, adult, female, male, young adult
2 autores
- Espen Bjørkedal🇳🇴 · autor de correspondenciaUiT The Arctic University of Norway
- Magne Arve Flaten🇳🇴UiT The Arctic University of Norway
Resumen
El texto original del estudio, en el idioma en que se publicó.
Rationale
In a randomised placebo-controlled clinical trial it is assumed that psychosocial effects of the treatment, regression to the mean and spontaneous remission are identical in the drug and placebo group. Consequently, any difference between the groups can be ascribed to the pharmacological effects. Previous studies suggest that side effects of drugs can enhance expectancies of treatment effects in the drug group compared to the placebo group, and thereby increase placebo responses in the drug group compared to the placebo group.
Objectives
The hypothesis that side effects of drugs can enhance expectancies and placebo responses was tested.
Method
Painful laser stimuli were delivered to 20 healthy subjects before and after administration of a drink with 0 or 4 mg/kg caffeine. The drink was administered either with information that it contained a painkiller or that it was a placebo. Laser-evoked potentials and reports of pain, expectancy, arousal and stress were measured.
Results
Four milligrammes per kilogramme of caffeine reduced pain. Information that a painkiller was administered increased the analgesic effect of caffeine compared to caffeine administered with no drug information. This effect was mediated by expectancies. Information and expectancies had no effect on pain intensity when 0 mg/kg was administered.
Conclusion
The analgesic effect of caffeine was increased by information that a painkiller was administered. This was due to an interaction of the pharmacological action of the drug and expectancies. Hence, psychosocial effects accompanying a treatment can differ when an active drug is administered compared to a placebo.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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