Effect of walnut-enriched meat on the relationship between VCAM, ICAM, and LTB4 levels and PON-1 activity in ApoA4 360 and PON-1 allele carriers at increased cardiovascular risk
Canales A, Sánchez-Muniz FJ, Bastida S, Librelotto J, Nus M, Corella D, Guillen M, Benedi J
European journal of clinical nutrition · 36 citas
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Alimentación controladaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Jiangsu National Synergistic Innovation Center for Advanced Materials
Según 1 financiador declarado.
Publicación
- Publicado
- 2011-03-16 · Eur J Clin Nutr · vol. 65 · número 6 · págs. 703–710
- Editorial
- Springer Nature
- Citado
- 47 citas · más que el 87% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- De pago
- Áreas de investigación
- Paraoxonase enzyme and polymorphisms · Nuts composition and effects · Fatty Acid Research and Health
- Palabras clave
- paraoxonase 1, apolipoprotein A4, soluble VCAM-1, soluble ICAM-1, leukotriene B4, cardiovascular risk, gene-diet interaction, inflammatory markers, HDL cholesterol
- MeSH
- humans, juglans, nuts, cardiovascular diseases, aryldialkylphosphatase, leukotriene b4, apolipoproteins a, apolipoprotein a-i, cell adhesion molecules, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, inflammation mediators, plant preparations, diet, risk factors, polymorphism, genetic, food, fortified, meat, middle aged, female, male, cholesterol, hdl
8 autores
- A Canales🇪🇸Universidad Complutense de Madrid
- Francisco José Sánchez-Muniz🇪🇸 · autor de correspondenciaUniversidad Complutense de Madrid
- Sara Bastida🇪🇸Universidad Complutense de Madrid
- Josana Librelotto🇪🇸Universidad Complutense de Madrid
- Meritxell Nus🇪🇸Universidad Complutense de Madrid
- Dolores Corella🇪🇸Universitat de València; Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red
- Marisa Guillén🇪🇸Universitat de València; Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red
- Juana Benedı́🇪🇸Universidad Complutense de Madrid
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/objective
Cardiovascular risk depends largely on paraoxonase (PON-1) and apolipoprotein A4 (APOA4) gene polymorphisms. To compare the effects of consumption of walnut-enriched meat versus low-fat meat (LM) on selected soluble adhesion molecules and leukotrienes (LTB4).
Subjects/methods
In all 22 subjects at increased cardiovascular risk were taken. It is a non-blinded, cross-over, placebo-controlled study. Two 5-week experimental periods separated by 4-6 week wash-out interval. Participants consumed walnut-enriched meat during one period and LM during the other. Diet characteristics, HDLc, Apo A1, paraoxonase, sVCAM-1, sICAM-1 and LTB4 were analysed. PON-1 55, PON-1 192 and APOA4 360 polymorphism effects were also assessed.
Results
Individuals consuming walnut-enriched meat displayed higher paraoxonase activity (P<0.001), lower levels of sICAM and aVCAM (P=0.046, P=0.012, respectively) and leukotriene B4 (P=0.044), and lower paraoxonase-1/HDLc and paraoxonase-1/Apo A1 ratios (both, P<0.001) than those consuming LM. Paraoxonase levels correlated negatively with those of sICAM (r=-0.471, P<0.01). Significant decreases (at least P<0.05) were observed in sICAM concentrations in PON-1 55LM+MM, PON-1 QQ192 and APOA4-2 carriers while decreases in sVCAM in QR+RR and APOA4-1 carriers were observed. Paraoxonase-1/HDLc and paraoxonase-1/Apo A1 ratios were significantly influenced by paraoxonase polymorphisms.
Conclusions
Walnut-enriched meat appears as a functional meat as consumed in the framework of a mix diet lowered the concentration of some selected inflammatory chemoattractant biomarkers. This effect was largely influenced by PON-1 and Apo A4-360 polymorphisms.
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