Circulating levels of vitamin D and colon and rectal cancer: the Physicians' Health Study and a meta-analysis of prospective studies
Lee JE, Li H, Chan AT, Hollis BW, Lee IM, Stampfer MJ, Wu K, Giovannucci E, Ma J
Cancer prevention research (Philadelphia, Pa.) · 145 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Women's Health Initiative
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Cancer Institute (U54CA155626); National Cancer Institute (CA 42182); National Cancer Institute (CA137178); National Cancer Institute (R01 CA034944); National Heart, Lung, and Blood Institute (R01 HL026490); National Cancer Institute (R01-CA137178); National Cancer Institute (CA90598); National Cancer Institute (CA-097193); National Cancer Institute (R01CA097193); National Cancer Institute (CA 40360); National Heart, Lung, and Blood Institute (R01HL034595); National Cancer Institute (CA-58684); National Cancer Institute (R01 CA040360); National Cancer Institute (R01 CA042182)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2011-03-24 · Cancer Prev Res (Phila) · vol. 4 · número 5 · págs. 735–743
- Editorial
- American Association for Cancer Research
- Citado
- 200 citas · más que el 89% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Colorectal Cancer Screening and Detection
- Palabras clave
- vitamin D, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, colon cancer, rectal cancer, colorectal cancer, circulating vitamin D levels, cancer risk, Physicians' Health Study
- MeSH
- colon, rectum, humans, colonic neoplasms, rectal neoplasms, vitamin d, prognosis, case-control studies, prospective studies, double-blind method, adult, aged, aged, 80 and over, middle aged, physicians, male, randomized controlled trials as topic
9 autores
- Jung Eun Lee🇺🇸🇰🇷Brigham and Women's Hospital; Harvard University; Sookmyung Women's University; Massachusetts General Hospital
- Haojie Li🇺🇸🇰🇷Brigham and Women's Hospital; Harvard University; Sookmyung Women's University; Massachusetts General Hospital
- Andrew Tan Chan🇺🇸🇰🇷Brigham and Women's Hospital; Harvard University; Sookmyung Women's University; Massachusetts General Hospital
- Bruce W. Hollis🇺🇸🇰🇷Brigham and Women's Hospital; Harvard University; Sookmyung Women's University; Massachusetts General Hospital
- I‐Min Lee🇺🇸🇰🇷Brigham and Women's Hospital; Harvard University; Sookmyung Women's University; Massachusetts General Hospital
- Meir J. Stampfer🇺🇸🇰🇷Brigham and Women's Hospital; Harvard University; Sookmyung Women's University; Massachusetts General Hospital
- Kana Wu🇺🇸🇰🇷Brigham and Women's Hospital; Harvard University; Sookmyung Women's University; Massachusetts General Hospital
- Edward L. Giovannucci🇺🇸🇰🇷Brigham and Women's Hospital; Harvard University; Sookmyung Women's University; Massachusetts General Hospital
- Jing Ma🇺🇸🇰🇷 · autor de correspondenciaBrigham and Women's Hospital; Harvard University; Sookmyung Women's University; Massachusetts General Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
It remains unknown whether increased risk with low levels of vitamin D is present for colon and/or rectal cancer. To investigate the association between circulating vitamin D levels and colon and rectal cancer, we examined the associations between plasma levels of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] and colon and rectal cancer in the Physicians' Health Study and then conducted a meta-analysis of eight prospective studies of circulating levels of 25(OH)D and colon and rectal cancers, including the Physicians' Health Study. Study-specific ORs and 95% CIs were pooled by using a random-effects model. A total of 1,822 colon and 868 rectal cancers were included in the meta-analysis. We observed a significant inverse association for colorectal cancer (OR = 0.66; 95% CI, 0.54-0.81), comparing top versus bottom quantiles of circulating 25(OH)D levels. The inverse association was stronger for rectal cancer (OR = 0.50 for top versus bottom quantiles; 95% CI, 0.28-0.88) than colon cancer (OR = 0.77; 95% CI, 0.56-1.07; P value for difference between colon and rectal cancer = 0.20). These data suggest an inverse association between circulating 25(OH)D levels and colorectal cancer, with a stronger association for rectal cancer.
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