Coenzyme Q10 terclatrate and creatine in chronic heart failure: a randomized, placebo-controlled, double-blind study
Fumagalli S, Fattirolli F, Guarducci L, Cellai T, Baldasseroni S, Tarantini F, Di Bari M, Masotti G, Marchionni N
Clinical cardiology · 32 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-04-01 · Clin Cardiol · vol. 34 · número 4 · págs. 211–217
- Editorial
- Wiley
- Citado
- 48 citas · más que el 81% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 34 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Coenzyme Q10 studies and effects · Heart Failure Treatment and Management · Cardiovascular and exercise physiology
- Palabras clave
- coenzyme Q10, creatine, chronic heart failure, left ventricular systolic dysfunction, mitochondrial dysfunction, micronutrient supplementation, exercise tolerance, peak oxygen uptake, health-related quality of life, physical performance
- MeSH
- humans, deficiency diseases, chronic disease, creatine, ubiquinone, drug combinations, stroke volume, exercise test, treatment outcome, administration, oral, chi-square distribution, double-blind method, placebo effect, oxygen consumption, ventricular function, left, exercise tolerance, time factors, quality of life, dietary supplements, aged, female, male, heart failure, medication adherence
9 autores
- Stefano Fumagalli🇮🇹 · autor de correspondenciaAzienda Ospedaliero-Universitaria Careggi; University of Florence
- Francesco Fattirolli🇮🇹Azienda Ospedaliero-Universitaria Careggi; University of Florence
- Lorenzo Guarducci🇮🇹Azienda Ospedaliero-Universitaria Careggi; University of Florence
- Tommaso Cellai🇮🇹Azienda Ospedaliero-Universitaria Careggi; University of Florence
- Samuele Baldasseroni🇮🇹Azienda Ospedaliero-Universitaria Careggi; University of Florence
- Francesca Tarantini🇮🇹Azienda Ospedaliero-Universitaria Careggi; University of Florence
- Mauro Di Bari🇮🇹Azienda Ospedaliero-Universitaria Careggi; University of Florence
- Giulio Masotti
- Niccolò Marchionni🇮🇹Azienda Ospedaliero-Universitaria Careggi; University of Florence
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Studies have suggested that micronutrient deficiency has some role in the progression of chronic heart failure (CHF).
Hypothesis
Oral supplementation with coenzyme Q(10) (CoQ(10)) and creatine may reduce mitochondrial dysfunction that contributes to impaired physical performance in CHF.
Methods
We conducted a randomized, double-blind, placebo-controlled trial to determine the effect of a mixture of water-soluble CoQ(10) (CoQ(10) terclatrate; Q-ter) and creatine on exercise tolerance and health-related quality of life. Exercise tolerance was measured as total work capacity (kg·m) and peak oxygen consumption (VO(2), mL/min/kg), both from a cardiopulmonary exercise test. Health-related quality of life was measured by the Sickness Impact Profile (SIP) in CHF secondary to left ventricular systolic dysfunction (left ventricular ejection fraction ≤ 35%). After baseline assessment, 67 patients with stable CHF were randomized to receive Q-ter 320 mg + creatine 340 mg (n = 35) or placebo (n = 32) once daily for 8 weeks.
Results
At multivariate analysis, 8-week peak VO(2) was significantly higher in the active treatment group than in the placebo group (+1.8 ± 0.9 mL/min/kg, 95% CI: 0.1-3.6, P < 0.05). No untoward effects occurred in either group.
Conclusions
This study suggests that oral Q-ter and creatine, added to conventional drug therapy, exert some beneficial effect on physical performance in stable systolic CHF. Results may support the design of larger studies aimed at assessing the long-term effects of this treatment on functional status and harder outcomes.
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