Replacing dairy fat with rapeseed oil causes rapid improvement of hyperlipidaemia: a randomized controlled study
Iggman D, Gustafsson IB, Berglund L, Vessby B, Marckmann P, Risérus U
Journal of internal medicine · 58 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-04-05 · J Intern Med · vol. 270 · número 4 · págs. 356–364
- Editorial
- Wiley
- Citado
- 86 citas · más que el 95% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Nuts composition and effects
- Palabras clave
- Medicine, Rapeseed, Randomized controlled trial, Food science, Environmental health, Internal medicine
- MeSH
- humans, cholesterol, dietary fats, unsaturated, fatty acids, fatty acids, monounsaturated, lipoproteins, plant oils, analysis of variance, cross-over studies, double-blind method, dairy products, sweden, female, male, hyperlipidemias, rapeseed oil
6 autores
- David Iggman🇸🇪 · autor de correspondenciaUppsala University; Center for Clinical Research Dalarna
- Inga‐Britt Gustafsson🇸🇪Örebro University
- Lars Berglund🇸🇪Uppsala University
- B. Vessby🇸🇪Uppsala University
- Peter Marckmann🇩🇰University of Southern Denmark; Odense University Hospital
- Ulf Risérus🇸🇪 · autor de correspondenciaUppsala University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Rapeseed oil (RO), also known as canola oil, principally contains the unsaturated fatty acids 18:1n-9, 18:2n-6 and 18:3n-3 and may promote cardiometabolic health.
Objective
To investigate the effects on lipoprotein profile, factors of coagulation and insulin sensitivity of replacing a diet rich in saturated fat from dairy foods (DF diet) with a diet including RO-based fat (RO diet).
Design
During a 2×3-week randomized, controlled, cross-over trial, 20 free-living hyperlipidaemic subjects were provided with isocaloric test diets that differed in fat composition alone. Blood lipoprotein profile, coagulation and fibrinolytic factors and insulin sensitivity (euglycaemic clamp) were determined before and after the dietary intervention.
Results
All subjects completed the study, and compliance was high according to changes in serum fatty acids. The RO diet, but not the DF diet, reduced the levels of serum cholesterol (-17%), triglycerides (-20%) and low-density lipoprotein cholesterol (-17%), cholesterol/high-density lipoprotein (HDL) cholesterol ratio (-21%), apolipoprotein (apo) B/apo A-I ratio (-4%) and factor VII coagulant activity (FVIIc) (-5%) from baseline. These changes were significantly different between the diets (P=0.05 to P<0.0001), except for FVIIc (P=0.1). The RO diet, but not the DF diet, modestly increased serum lipoprotein(a) (+6%) and tended to increase the glucose disappearance rate (K-value, +33%). HDL cholesterol, insulin sensitivity, fibrinogen and tissue plasminogen activator inhibitor-1 levels did not change from baseline or differ between the two diets.
Conclusions
In a diet moderately high in total fat, replacing dairy fat with RO causes a rapid and clinically relevant improvement in serum lipoprotein profile including lowering of triglycerides in hyperlipidaemic individuals.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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