Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial
Bahadoran Z, Mirmiran P, Hosseinpanah F, Hedayati M, Hosseinpour-Niazi S, Azizi F
European journal of clinical nutrition · 72 citas
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Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-05-11 · Eur J Clin Nutr · vol. 65 · número 8 · págs. 972–977
- Editorial
- Springer Nature
- Citado
- 107 citas · más que el 94% de estudios similares · 4.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Genomics, phytochemicals, and oxidative stress · Natural Antidiabetic Agents Studies
- Palabras clave
- broccoli sprouts, type 2 diabetes, oxidative stress, total antioxidant capacity, total oxidant status, oxidative stress index, malondialdehyde, oxidized LDL, dietary supplementation, isothiocyanates
- MeSH
- humans, brassica, diabetes mellitus, type 2, malondialdehyde, lipoproteins, ldl, plant preparations, powders, antioxidants, phytotherapy, double-blind method, oxidative stress, dose-response relationship, drug, adolescent, adult, middle aged, female, male, young adult, biomarkers
6 autores
- Zahra Bahadoran🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Parvin Mirmiran🇮🇷 · autor de correspondenciaNational Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Farhad Hosseinpanah🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Mehdi Hedayati🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Somayeh Hosseinpour‐Niazi🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Fereidoun Azizi🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/objectives
In vitro and animal studies have reported that young broccoli sprouts improve oxidative stress status in diabetic condition. The objective of this double-blind, placebo-controlled, randomized clinical trial was to investigate the effects of broccoli sprouts powder (BSP) on some oxidative stress parameters in type 2 diabetes patients.
Subjects/methods
A total of 81 patients with type 2 diabetes were randomly assigned to one of three treatment groups for 4 weeks. The groups received either 10 g/d BSP (n=27), 5 g/d BSP (n=29) or placebo (n=25). Serum total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and oxidized low density lipoprotein (LDL) cholesterol were measured at baseline and at 4 weeks after treatment.
Results
In all, 63 patients in three groups were included in the analysis: 10 g/d BSP (n=21), 5 g/d (n=22) and placebo (n=20). After 4 weeks, consumption of BSP resulted in significant decrease in MDA (P=0.001 for treatment effect), oxidized low density lipoprotein cholesterol (P=0.03 for treatment effect), OSI (P=0.001 for treatment effect) and significant increase in TAC (P=0.001 for treatment effect). No effects were found on TOS.
Conclusion
BSP had favorable effects on oxidative stress status in type 2 diabetes patients.
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