Increasing water intake by 2 liters reduces crystallization risk indexes in healthy subjects
de La Guéronnière V, Le Bellego L, Jimenez IB, Dohein O, Tack I, Daudon M
Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica · 11 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2011-03-01 · Arch Ital Urol Androl · vol. 83 · número 1 · págs. 43–50
- Editorial
- National Institutes of Health
- Citado
- 16 citas · más que el 74% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Kidney Stones and Urolithiasis Treatments · Gout, Hyperuricemia, Uric Acid · Crystallization and Solubility Studies
- Palabras clave
- water intake, urinary lithiasis, kidney stones, 24-hour urine, urea excretion, osmotic load, body mass index, waist circumference, fluid intake
- MeSH
- humans, crystallization, risk factors, drinking, adult, middle aged, female, male, urolithiasis
6 autores
- Viviane de la Guéronnière🇫🇷Danone (France)
- Laurent Le Bellego
- Inmaculada Buendía Jiménez
- Oriane Dohein
- Ivan Tack
- Michel Daudon
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The objective of the present study was to evaluate the effects of drinking 2 additional litres of water/day on several urinary risk factors for lithiasis in healthy subjects, through measurement of crystallization risk indices (Tiselius CRI).
Materials and methods
48 healthy subjects, aged 25 to 50 were studied for urinary parameters including CRI in the laboratory ward, for 24 hours. After this first period, they were randomized either to a 2L/d additional water intake (treated group) or usual fluid consumption (control group) for a 6 days period, which ended by a second measurement period in the laboratory ward for 24 hours.
Results
Total additional water intake was actually 1.3L/d on average in treated subjects, because subjects decreased other usual sources of fluid intake. In 24 hour urine, Tiselius CRI varied differently among treated subjects and controls between the 2 periods; male controls subjects experienced much higher values (above 2 in average in first morning urine sample) in the second period (p = 0.05). Of interest, in a transversal analysis, we observed a positive relation between BMI or waist circumference on the one hand, and with 24 hour urea excretion or osmotic load on the other hand.
Conclusion
These results show a beneficial effect of a final 1.3L additional water intake on Tiselius CRI in healthy subjects.
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