Financiado en parte por Dairy Farmers of Canada
The ratio of serum 24,25-dihydroxyvitamin D(3) to 25-hydroxyvitamin D(3) is predictive of 25-hydroxyvitamin D(3) response to vitamin D(3) supplementation
Wagner D, Hanwell HE, Schnabl K, Yazdanpanah M, Kimball S, Fu L, Sidhom G, Rousseau D, Cole DE, Vieth R
The Journal of steroid biochemistry and molecular biology · 127 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Dairy Farmers of Canada
- Gobierno
- Natural Sciences and Engineering Research Council of Canada
Según 2 financiadores declarados.
Publicación
- Publicado
- 2011-05-20 · J Steroid Biochem Mol Biol · vol. 126 · número 3-5 · págs. 72–77
- Editorial
- Elsevier BV
- Citado
- 167 citas · más que el 98% de estudios similares · 8.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Parathyroid Disorders and Treatments · Nutrition and Health Studies
- Palabras clave
- 24,25-dihydroxyvitamin D3, 25-hydroxyvitamin D3, vitamin D3 supplementation, vitamin D metabolism, vitamin D catabolism, vitamin D deficiency, vitamin D status biomarkers
- MeSH
- humans, cholecalciferol, 24,25-dihydroxyvitamin d 3, vitamin d, placebos, chromatography, liquid, double-blind method, time factors, dietary supplements, adult, female, male, tandem mass spectrometry, biomarkers, pharmacological, young adult
10 autores
- Dennis Wagner🇨🇦 · autor de correspondenciaMount Sinai Hospital; University of Toronto
- Heather Hanwell🇨🇦Mount Sinai Hospital; University of Toronto
- Kareena Leanne Schnabl🇨🇦University of Toronto; Hospital for Sick Children
- Mehrdad Yazdanpanah🇨🇦Hospital for Sick Children
- Samantha Kimball🇨🇦Mount Sinai Hospital; University of Toronto
- Lei Fu🇨🇦University of Toronto
- Gloria Sidhom🇪🇬National Research Centre
- Dérick Rousseau🇨🇦Toronto Metropolitan University
- David E.C. Cole🇨🇦University of Toronto
- Reinhold Vieth🇨🇦Mount Sinai Hospital; University of Toronto
Resumen
El texto original del estudio, en el idioma en que se publicó.
24,25-Dihydroxyvitamin D (24,25VD) is a major catabolite of 25-hydroxyvitamin D (25VD) metabolism, and may be physiologically active. Our objectives were to: (1) characterize the response of serum 24,25VD(3) to vitamin D(3) (VD(3)) supplementation; (2) test the hypothesis that a higher 24,25VD(3) to 25VD(3) ratio (24,25:25VD(3)) predicts 25VD(3) response. Serum samples (n=160) from wk 2 and wk 6 of a placebo-controlled, randomized clinical trial of VD(3) (28,000IU/wk) were analyzed for serum 24,25VD(3) and 25VD(3) by mass spectrometry. Serum 24,25VD(3) was highly correlated with 25VD(3) in placebo- and VD(3)-treated subjects at each time point (p<0.0001). At wk 2, the 24,25:25VD(3) ratio was lower with VD(3) than with placebo (p=0.035). From wk 2 to wk 6, the 24,25:25VD(3) ratio increased with the VD(3) supplement (p<0.001) but not with placebo, such that at wk 6 this ratio did not significantly differ between groups. After correcting for potential confounders, we found that 24,25:25VD(3) at wk 2 was inversely correlated to the 25VD(3) increment by wk 6 in the supplemented group (r=-0.32, p=0.02) but not the controls. There is a strong correlation between 24,25VD(3) and 25VD(3) that is only modestly affected by VD(3) supplementation. This indicates that the catabolism of 25VD(3) to 24,25VD(3) rises with increasing 25VD(3). Furthermore, the initial ratio of serum 24,25VD(3) to 25VD(3) predicted the increase in 25VD(3). The 24,25:25VD(3) ratio may therefore have clinical utility as a marker for VD(3) catabolism and a predictor of serum 25VD(3) response to VD(3) supplementation.
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